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Celecoxib administration reduced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ injury in septic rats

Biomedicine and Pharmacotherapy · Şubat 2017

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YÖKSİS Kayıtları
Celecoxib administration reduced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ injury in septic rats
Biomedicine & Pharmacotherapy · 2016 SCI-Expanded
Prof. Dr. CEYHAN UĞURLUOĞLU →
Celecoxib administration reduced mortality mesenteric hypoperfusion aortic dysfunction and multiple organ injury in septic rats
Biomedicine Pharmacotherapy · 2017 SCI-Expanded
Prof. Dr. CEYHAN UĞURLUOĞLU →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 10 kaydı bulundu.

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Celecoxib administration reduced mortality mesenteric hypoperfusion aortic dysfunction and multiple organ injury in septic rats
2017 ISSN: 07533322 SCI-Expanded
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Femtosecond laser induced photodynamic therapy on 5-ALA treated SKMEL-30 cells: An efficient theranostic strategy to combat melanoma
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Celecoxib administration reduced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ injury in septic rats
2016 ISSN: 0753-3322 SCI-Expanded
Prof. Dr. CEYHAN UĞURLUOĞLU →

Makale Bilgileri

Dergi Biomedicine and Pharmacotherapy
ISSN07533322
Yayın TarihiŞubat 2017
Cilt / Sayfa86 · 583-589
DOI10.1016/j.biopha.2016.11.102
Scopus ID2-s2.0-85006880740
Özet Background The cyclooxygenase (COX)-2 overexpression is associated with vascular injury and multiple organ failure in sepsis. However, constitutive COX-1 and basal COX-2 expressions have physiological effects. We aimed to investigate the effects of partial and selective COX-2 inhibition without affecting constitutive COX-1 and basal COX-2 activities by celecoxib on mesenteric artery blood flow (MABF), vascular reactivity, oxidative and inflammatory injuries, and survival in septic rats accomplished by cecal ligation and puncture (CLP). Methods Wistar rats were allocated into Sham, CLP, Sham + celecoxib, CLP + celecoxib subgroups. 2 h after Sham and CLP operations, celecoxib (0.5 mg/kg) or vehicle (saline; 1 mL/kg) was administered orally to rats. 18 h after drug administrations, MABF and responses of isolated aortic rings to phenylephrine were measured. Tissue samples were obtained for biochemical and histopathological examinations. Furthermore, survival rate was monitored throughout 96 h. Results Celecoxib ameliorated mesenteric hypoperfusion and partially improved aortic dysfunction induced by CLP. Survival rate was%0 at 49th h in CLP group, but in CLP + celecoxib group it was 42.8% at the end of 96 h. Serum AST, ALT, LDH, BUN, Cr and inflammatory cytokine (tumor necrosis factor-alpha, interleukin-1 beta and interleukin-6) levels were increased in CLP group that were prevented by celecoxib. The decreases in liver and spleen glutathione levels and the increases in liver, lung, spleen and kidney malondialdehyde levels in CLP group were blocked by celecoxib. The histopathological protective effects of celecoxib on organ injury due to CLP were also observed. Conclusions Celecoxib has protective effects on sepsis due to its preservative effects on mesenteric perfusion, aortic function and its anti-inflammatory and antioxidative effects.

Yazarlar (6)

1
Erdem Kamil Ozer
2
Mustafa Tugrul Goktas
3
Ibrahim Kilinc
4
Hulagu Bariskaner
ORCID: 0000-0001-6600-4635
5
Ceyhan Uğurluoğlu
6
Alper Bektas Iskit

Anahtar Kelimeler

Celecoxib Mesenteric arterial blood flow Sepsis Survival and multiple organ damage Vascular hyporeactivity

Kurumlar

Ankara Yildirim Beyazit University
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Biomedicine and Pharmacotherapy
Q1 OA
SJR Skoru1,775
H-Index169
YayıncıElsevier Masson s.r.l.
ÜlkeFrance
Medicine (miscellaneous) (Q1)
Pharmacology (Q1)
Dergi sayfasına git

Metrikler

24
Atıf
6
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

HB
HÜLAGU BARIŞKANER
Prof. Dr.

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