Scopus
YÖKSİS Eşleşti
Thymoquinone protects against the sepsis induced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ damage in rats
Pharmacological Reports · Ağustos 2017
YÖKSİS Kayıtları
Thymoquinone protects against the sepsis induced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ damage in rats
Pharmacological Reports · 2017 SSCI
PROFESÖR HÜLAGU BARIŞKANER →
Thymoquinone protects against the sepsis induced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ damage in rats
Pharmacological Reports · 2017 SCI-Expanded
PROFESÖR CEYHAN UĞURLUOĞLU →
Thymoquinone protects against the sepsis induced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ damage in rats
Pharmacological Reports · 2017 SSCI
PROFESÖR CEYHAN UĞURLUOĞLU →
Makale Bilgileri
DergiPharmacological Reports
Yayın TarihiAğustos 2017
Cilt / Sayfa69 · 683-690
Scopus ID2-s2.0-85019929237
Özet
Background Thymoquinone (TQ) is a potent cytoprotective, antioxidant and anti-inflammatory agent. We aimed to investigate the possible protective effects of TQ on survival, mesenteric artery blood flow (MABF), vascular reactivity, oxidative and inflammatory injuries in a murine sepsis model induced by cecal ligation and puncture (CLP). Methods Wistar rats were divided into the following four groups: Sham, CLP, Sham + TQ and CLP + TQ. TQ (1 mg/kg/day) or vehicle (dimethyl sulfoxide, 1 mL/kg/day) was intraperitoneally injected for 3 days. At 4th day Sham or CLP operation was applied. 20 h after the operations, MABF and contractile responses of isolated aortic rings to phenylephrine were measured. Tissue samples were obtained for histopathological and biochemical examinations. Also, survival rates were recorded throughout 96 h. Results TQ ameliorated mesenteric hypoperfusion and partially attenuated aortic dysfunction induced by CLP. Survival rate was %0 at 42nd h in CLP group, but in CLP + TQ group it was 33.4% at the end of 96 h. Serum levels of AST, ALT, LDH, BUN, Cr and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1 beta and interleukin-6) increased in CLP group that were prevented by TQ. The decreases in liver, spleen and kidney glutathione levels and the increases in liver, lung, kidney and spleen malondialdehyde levels induced by CLP were inhibited by TQ. The histopathological protective effects of TQ on multiple organ damage due to CLP were also observed. Conclusion TQ has ameliorative effects on sepsis due to its protective effects on mesenteric perfusion, contractile function of aorta and its anti-inflammatory and antioxidative effects.
Yazarlar (7)
1
Erdem Kamil Ozer
2
Mustafa Tugrul Goktas
3
Aysun Toker
4
Sultan Pehlivan
5
Hulagu Bariskaner
ORCID: 0000-0001-6600-4635
6
Ceyhan Uğurluoğlu
7
Alper Bektas Iskit
Anahtar Kelimeler
Multiple organ damage
Sepsis
Survival
Thymoquinone
Vascular hyporeactivity and mesenteric arterial blood flow
Kurumlar
Ankara Group Administration of the Council of Forensic Medicine
Ankara Turkey
Ankara Yildirim Beyazit University
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
19
Atıf
7
Yazar
5
Anahtar Kelime