Scopus
YÖKSİS Eşleşti
Effects of Carvacrol on Survival, Mesenteric Blood Flow, Aortic Function and Multiple Organ Injury in a Murine Model of Polymicrobial Sepsis
Inflammation · Ekim 2017
YÖKSİS Kayıtları
Effects of Carvacrol on Survival, Mesenteric Blood Flow, Aortic Function and Multiple Organ Injury in a Murine Model of Polymicrobial Sepsis
Inflammation · 2017 SCI
PROFESÖR CEYHAN UĞURLUOĞLU →
Makale Bilgileri
DergiInflammation
Yayın TarihiEkim 2017
Cilt / Sayfa40 · 1654-1663
Scopus ID2-s2.0-85021226614
Özet
Carvacrol (CRV) has strong cytoprotective, antioxidant, and anti-inflammatory properties. We aimed to demonstrate the possible protective effects of CRV on survival, mesenteric artery blood flow (MBF), vascular reactivity, and oxidative and inflammatory injuries in a murine model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). Wistar rats were allocated into the following four groups: Sham, CLP, Sham + CRV, and CLP + CRV. The animals were orally administered with CRV (80 mg/kg/day) or vehicle (corn oil; 1 mL/kg/day) for 7 days. At the eighth day, Sham or CLP procedure was applied. Twenty hours after the operations, MBF and contractile responses of isolated aortic preparations to phenylephrine were measured. Tissue samples were obtained for biochemical and histopathological assessments. Additionally, survival rates were recorded throughout 96 h. CRV administration improved the mesenteric perfusion, contractile function of aorta, and survival after CLP. CRV substantially prevented the elevations in the levels of LDH, BUN, Cr, and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1 beta and interleukin-6) but could not prevent the elevations of AST and ALT after CLP. The decreased liver, kidney, and spleen glutathione levels and increased liver, kidney, lung, and spleen malondialdehyde levels induced by CLP were substantially restored by CRV. Also, histopathological protective effects of CRV on multiple organ damage due to CLP were observed. CRV possesses strong ameliorative effects on sepsis due to its protective effects on mesenteric perfusion and aortic function and its antioxidative and anti-inflammatory effects.
Yazarlar (6)
1
Erdem Kamil Ozer
2
Mustafa Tugrul Goktas
3
Aysun Toker
4
Hulagu Bariskaner
ORCID: 0000-0001-6600-4635
5
Ceyhan Uğurluoğlu
6
Alper Bektas Iskit
Anahtar Kelimeler
Carvacrol
mesenteric perfusion
multiple organ function
sepsis
survival
vascular reactivity
Kurumlar
Ankara Yildirim Beyazit University
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
12
Atıf
6
Yazar
6
Anahtar Kelime