Scopus
YÖKSİS Eşleşti
Arachidonic Acid Metabolites in Neurologic Disorders
CNS and Neurological Disorders - Drug Targets · Şubat 2022
YÖKSİS Kayıtları
Arachidonic Acid Metabolites in Neurologic Dis
CNS & Neurological Disorders - Drug Targets · 2022 SCI
PROFESÖR HÜLAGU BARIŞKANER →
Arachidonic Acid Metabolites in Neurologic Disorders
CNS & Neurological Disorders - Drug Targets · 2022 SCI-Expanded
PROFESÖR ŞEREFNUR ÖZTÜRK →
Makale Bilgileri
DergiCNS and Neurological Disorders - Drug Targets
Yayın TarihiŞubat 2022
Cilt / Sayfa21 · 150-159
Scopus ID2-s2.0-85115664396
Özet
Background and Objective: Arachidonic acid (ARA) is essential for the fluidity, selective permeability, and flexibility of the cell membrane. It is an important factor for the function of all cells, particularly in the nervous system, immune system, and vascular endothelium. ARA is the second most common polyunsaturated fatty acid in the phospholipids of the nerve cell membrane after docosahexaenoic acid. ARA metabolites have many kinds of physiologic roles. The major action of ARA metabolites is the promotion of the acute inflammatory response, mediated by the production of pro-inflammatory mediators such as PGE2 and PGI2, followed by the formation of lipid mediators, which have pro-resolving effects. Another important action of ARA derivatives, especially COX, is the regulation of vascular reactivity through PGs and TXA2. There is significant involvement of ARA metabolites in neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and neuropsychiatric disorders. ARA derivatives also make an important contribution to acute stroke, global ischemia, subarachnoid hemorrhage, and anticoagulation-related hemorrhagic transformation. Conclusion: In this review, we have discussed experimental and human study results of neurologic disorders related to ARA and its metabolites in line with treatment options.
Yazarlar (4)
1
Oguzhan Kursun
2
Hulya Karatas
3
Hulagu Bariskaner
ORCID: 0000-0001-6600-4635
4
Şerefnur Öztürk
Anahtar Kelimeler
Arachidonic acid
COX
LOX
Neurodegenerative diseases
PGs
Stroke
Kurumlar
Ankara City Hospital
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
18
Atıf
4
Yazar
6
Anahtar Kelime