Scopus
YÖKSİS Eşleşti
Integrative analysis of serum-derived exosomal lncRNA profiles of alveolar echinococcosis patients
Gene · Ocak 2024
YÖKSİS Kayıtları
Integrative analysis of serum-derived exosomal lncRNA profiles of alveolar
echinococcosis patients
Gene · 2023 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ MUHAMMED HÜDAİ ÇULHA →
Makale Bilgileri
DergiGene
Yayın TarihiOcak 2024
Cilt / Sayfa892
Scopus ID2-s2.0-85173285774
Özet
Alveolar echinococcosis is a severe zoonotic disease caused by the pseudotumoral intrahepatic development of the larval stage of the tapeworm Echinococcus multilocularis. The diagnosis of alveolar echinococcosis is hard since it has features of liver cancer. LncRNAs are among the non-coding RNAs that have received the most attention in recent biomarker studies. Here, we aimed to identify the serum-derived exosomal lncRNAs associated with alveolar echinococcosis in humans with RNA-seq. After RNA isolation from exosomes, we performed RNA-seq to determine the lncRNAs. We found 8 target genes in the cis direction and a total of 6468 gene targets for lncRNAs were identified in the trans direction. Totally 621 mRNA transcripts were found as differentially expressed between the controls and patients. 278 of them were up-regulated and 343 were down-regulated. Moreover, 234 lncRNAs were found as differentially expressed between the controls and patients. 58 of them were up-regulated, and 176 of them were down-regulated. The top five biological pathways regulated by identified lncRNAs were detected in this study. As a result, it is thought that these results will contribute to lncRNA-based biomarker studies that can be used in the early diagnosis of alveolar echinococcosis in humans.
Yazarlar (11)
1
Selçuk Özdemir
ORCID: 0000-0001-7539-0523
2
Selim Çomaklı
3
Sefa Küçükler
4
Nurhak Aksungur
5
Necip Altundaş
6
Salih Kara
7
Ercan Korkut
8
Şeyma Aydın
ORCID: 0009-0009-5640-3363
9
Betül Bağcı
10
M. Hüdai Çulha
11
Gürkan Öztürk
Anahtar Kelimeler
Alveolar echinococcosis
Biomarker
Exosome
Liver
lncRNA
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Deutsches Zentrum für Neurodegenerative Erkrankungen
Bonn Germany
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
11
Yazar
5
Anahtar Kelime