Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Sulfasalazine treatment can cause a positive effecon lps-induced endotoxic rats
Experimental Animals · Ocak 2018
YÖKSİS Kayıtları
Sulfasalazine treatment can cause a positive effect on LPS-induced endotoxic rats
Experimental Animals · 2018 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ GONCA SÖNMEZ →
Makale Bilgileri
DergiExperimental Animals
Yayın TarihiOcak 2018
Cilt / Sayfa67 · 403-412
Scopus ID2-s2.0-85055825253
Erişim🔓 Açık Erişim
Özet
The aim of this study, was to determine the effect of sulfasalazine for different periods of time reduces disseminated intravascular coagulation, inflammation and organ damages by inhibiting the nuclear factor kappa beta pathway. The study was performed with 30 Wistar albino rats and the groups were established as Control group, LPS group; endotoxemia was induced with LPS, SL5 group: sulfasalazine (300 mg/kg, single dose daily) was administered for 5 days before the LPS-induced endotoxemia, and LS group: sulfasalazine (300 mg/kg, single dose) was administered similtenously with LPS. Hemogram, biochemical, cytokine (IL-1β, IL-6, IL-10, TNF-α) and acute phase proteins (HPT, SAA, PGE2) analyzes and oxidative status values were measured from blood samples at 3 and 6 h after the last applications in the all groups. The rats were euthanized at 6 h and mRNA levels of BCL2 and BAX genes were examined from liver and brain tissues. Sulfasalazine reduced the increased IL-1β, IL-6, TNF-α and PGE2 levels and significantly increased anti-inflammatory cytokine IL-10 levels. In addition, decreasing of ATIII level was prevented in the SL5 group, and decreasing of fibrinogen levels were prevented in the LS and SL5 groups within first 3 h. In LPS group, leukocyte and thrombocyte levels were decreased, however sulfasalazine application inhibited decreases of leukocyte levels in LS and SL5 groups. In addition, sulfasalazine inhibited the decrease of total antioxidant capacity and unchanged apoptosis in brain and liver. In conclusion, the use of sulfasalazine in different durations reduce the excessive inflammation of endotoxemia cases.
Yazarlar (4)
1
Burak Dik
2
Gonca Sönmez
3
Hatice Eser Faki
4
Emre Bahcivan
Anahtar Kelimeler
Antioxidant capacity
Cytokine
Endotoxemia
Oxidative status
Sulfasalazine
Kurumlar
Kafkas Üniversitesi
Kars Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
8
Atıf
4
Yazar
5
Anahtar Kelime