Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Cytotoxic and apoptotic effects of curcumin on d-17 canine osteosarcoma cell line[1]
Kafkas Universitesi Veteriner Fakultesi Dergisi · Ocak 2021
YÖKSİS Kayıtları
Kurkuminin D-17 Köpek Osteosarkom Hücre Hattı Üzerindeki Sitotoksik ve Apoptotik Etkileri
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2021 SCI-Expanded
Öğr. Gör. İREM BAYAR →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Evaluation of 305-Day Lactation Milk Yield Predictions from Pre-Peak Partial Milk Yields Using Some Data Mining Algorithms
2026 ISSN: 1300-6045 SCI-Expanded
Doç. Dr. ÖZCAN ŞAHİN →
Evaluation of 305-Day Lactation Milk Yield Predictions from Pre-Peak Partial Milk Yields Using Some Data Mining Algorithms
2026 ISSN: 1300-6045 SCI Q3
Doç. Dr. ÖZCAN ŞAHİN →
Hayvan Koruma Kavramı ve Biyoetik Çerçevesinde Yaban Hayatı Koruma ve Yaban Hayatı Geliştirme Sahaları
2012 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. GÖKHAN ASLIM →
Anatomy of the Cervical Canal in the Angora Goat Capra hircus
2010 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. KAMİL BEŞOLUK →
Bir Ceylanda Gazella gazella Generalize Reaktif Amiloidoz Olgusu
2013 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
İç Anadolu Bölgesi Konya Bölümü Folklorunda Ruminantların Paraziter Hastalıkları ve Tedavi Yöntemleri
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. GÖKHAN ASLIM →
Prevalence of Bartonella henselae in Pet and Stray Cats from the Aspect of Public Health: A Research Sample in the Concept of One Medicine - One Health
2015 ISSN: 1300-6045 SCI-Expanded Q3
Prof. Dr. MEHMET MADEN →
Fatty Acid Composition and Conjugated Linoleic Acid CLA Content of Some Commercial Milk in Turkey
2010 ISSN: 1300-6045 SCI-Expanded 5 atıf
Prof. Dr. GÖKHAN ZENGİN →
The potential of microarray databases to identify tissue specific genes
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. HİLAL ARIKOĞLU →
An Application of Bootstrap Technique in Animal Science EggYolk Color Sample
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. ALİ AYGÜN →
Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
2015 ISSN: 1300-6045 SCI-Expanded 2 atıf
Prof. Dr. RAMAZAN ÇÖL →
The Effect of Eugenol on Survival of Listeria monocytogenes Inoculated İnegöl Meatball
2015 ISSN: 1300-6045 SCI-Expanded Q4
Doç. Dr. ARİFE EZGİ TELLİ →
Türkiye’de Deney Hayvanı Kullanmaya Yetkili Kişilerin Hayvan Kullanımına Yönelik Tutumları
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. GÖKHAN ASLIM →
Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
2015 ISSN: 1300-6045 SCI-Expanded 2 atıf
Prof. Dr. HASAN GÜZELBEKTEŞ →
TheEffect of Eugenol on Survival of Listeria monocytogenes Inoculated İnegöl Meatball
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. ÜMİT GÜRBÜZ →
Structural and Functional Properties of the Distal Muscles ofFront and Hind Legs of Malakan Horses (Equus caballus)
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. MUSTAFA ORHUN DAYAN →
A Comparison of Different Analysis Methods for Milk Urea Nitrogen
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. MUSTAFA SELÇUK ALATAŞ →
Effects of Dietary Inactive Yeast and Live Yeast on Performance Egg Quality Traits Some Blood Parameters and Antibody Production to SRBC of Laying Hens
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. SUZAN YALÇIN →
İç Anadolu Bölgesi Konya Bölümü Folklorunda Ruminantların Paraziter Hastalıkları ve Tedavi Yöntemleri
2015 ISSN: 1300-6045 SSCI
Prof. Dr. AŞKIN YAŞAR →
Etanersept endotoksemi tedavisinde kullanılabilir mi
2013 ISSN: 1300-6045 SCI-Expanded 2 atıf
Prof. Dr. KAMİL ÜNEY →
Makale Bilgileri
ISSN13006045
Yayın TarihiOcak 2021
Cilt / Sayfa27 · 465-473
Scopus ID2-s2.0-85112456635
Erişim🔓 Açık Erişim
Özet
Cancer is a major health problem in dogs. Types of cancer seen in dogs include melanoma, Non-Hodgkin lymphoma, osteosarcoma, soft tissue sarcomas and prostate, breast, lung and colorectal carcinomas. Osteosarcoma (OSA) is the most common malignant primary bone tumor in domestic dogs. It constitutes 85% of skeletal tumors. It is derived from primitive bone cells that occur in both the appendicular (~75%) and axial (~25%) skeleton. The present study was intended to determine the cytotoxic and apoptotic effects of curcumin administration at certain doses and in certain periods on D-17 canine osteosarcoma cells. Canine osteosarcoma cells were treated with curcumin and the effects of it on proliferation were determined by WST-1, apoptosis by caspase 3/7 activity (MuseCaspase 3/7) and the ratio of proapoptotic Bax gene to antiapoptotic Bcl-2 gene expression level by qRT-PCR. Our data demonstrated that curcumin decreased cell proliferation and viability, ultimately inducing caspase 3/7 mediated apoptosis in treated D-17 canine osteosarcoma cells. Furthermore, the application of curcumin on canine osteosarcoma cells downregulated the expression of Bcl-2 and upregulated the expression of proapoptotic gene Bax. Thus, these results may provide a basis for further study of curcumin in the treatment of canine osteosarcoma.
Yazarlar (5)
1
Gamze Sevri Ekren Asici
2
Funda Kiral
3
İrem Bayar
4
Ayşegül Bildik
5
Pınar Alkım Ulutaş
ORCID: 0000-0002-2447-3027
Anahtar Kelimeler
Apoptozis
Bax/bcl-2
Canine osteosarcoma
Caspase 3/7
Curcumin
Kurumlar
Aydin Adnan Menderes University
Aydin Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Kafkas Universitesi Veteriner Fakultesi Dergisi
Q3
OA
SJR Skoru0,261
H-Index29
YayıncıKafkas University
ÜlkeTurkey
Veterinary (miscellaneous) (Q3)
Metrikler
3
Atıf
5
Yazar
5
Anahtar Kelime