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Proteases and Collagenase Enzymes Activity After Autologous Platelet-Rich Plasma, Bio-Physically Activated PRP and Stem Cells for the Treatment of Osteoarthritis in Dogs

Kafkas Universitesi Veteriner Fakultesi Dergisi · Ocak 2022

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YÖKSİS Kayıtları
Proteases and Collagenase Enzymes Activity Aft er Autologous PlateletRich Plasma, Bio-Physically Activated PRP and Stem Cells for the Treatment of Osteoarthritis in Dogs
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2022 SCI-Expanded
Doç. Dr. KURTULUŞ PARLAK →
Osteoartritli Köpeklerde Otolog Trombositten Zengin Plazma, Biyo-Fiziksel Olarak Aktive Edilmiş TZP ve Kök Hücre Tedavilerinin Proteaz ve Kollajenaz Enzim Aktivitesine Etkisi
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2022 SCI
Prof. Dr. KAMİL ÜNEY →
Proteases and Collagenase Enzymes Activity After Autologous PlateletRich Plasma, Bio-Physically Activated PRP and Stem Cells for the Treatment of Osteoarthritis in Dogs
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI · 2022 SCI-Expanded
Dr. Öğr. Üyesi GONCA SÖNMEZ →
Proteases and Collagenase Enzymes Activity After Autologous PlateletRich Plasma, Bio-Physically Activated PRP and Stem Cells for the Treatment of Osteoarthritis in Dogs
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI · 2022 SCI-Expanded
Prof. Dr. MUSTAFA ARICAN →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
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Anatomy of the Cervical Canal in the Angora Goat Capra hircus
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Bir Ceylanda Gazella gazella Generalize Reaktif Amiloidoz Olgusu
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Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
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Structural and Functional Properties of the Distal Muscles ofFront and Hind Legs of Malakan Horses (Equus caballus)
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Makale Bilgileri

Dergi Kafkas Universitesi Veteriner Fakultesi Dergisi
ISSN13006045
Yayın TarihiOcak 2022
Cilt / Sayfa28 · 437-445
DOI10.9775/kvfd.2022.27357
Scopus ID2-s2.0-85136296912
Erişim🔓 Açık Erişim
Özet The aim of this study was to evaluate the treatment of osteoarthritis (OA) in dogs with intra-articular injection of an (autologous platelet-rich plasma (PRP), Mesenchymal stem cells (MSCs), bio-physically activated platelet-rich plasma (B-PRP/plasma-poor platelets-PPP) and their combinations and to determine the changes in the levels of synovial fluid samples (inflammatory mediator, proteases (MMP-2 and MMP-9) and collagenase enzymes (MMP-1, MMP-8 and MMP-13) obtained from the joints. Total of 36 different breeds, sex, age and weight of dogs with osteoarthritis were used as the material. The groups were divided as Group I (PRP), Group II (MSCs), Group III (PRP + MSCs), Group IV (B-PRP), Group V (B-PRP + MSCs) and group VI (saline control). Only single injection was given. Metalloproteinases were measured by using the ELISA in preoperative and postoperative treatment of 0, 15th, 30th, 60th, and 90th days in synovial fluid samples. Clinical and radiographic examinations were performed on the 0, 15th, 30th, 60th, and 90th days. The results obtained from the PRP + MSCs combination group were more successful. It was also noted that successful results could be obtained with PRP alone or in combination with stem cells, especially if repeated intraarticular injections are required for osteoarthritis. New studies are needed to understand the effectiveness of B-PRP. Only B-PRP or stem cell combination was effective on many enzymes, but varying results were obtained with each case.

Yazarlar (5)

1
Mustafa Arican
ORCID: 0000-0001-8180-135X
2
Kamil Üney
ORCID: 0000-0002-8674-4873
3
Kurtuluş Parlak
ORCID: 0000-0002-8656-037X
4
Elgin Orçum Uzunlu
ORCID: 0000-0001-5356-8968
5
Gonca Sönmez

Anahtar Kelimeler

Anti-inflammatory effect Collagenase Dog Gelatinase Lameness Pain scores

Kurumlar

Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Kafkas Universitesi Veteriner Fakultesi Dergisi
Q3 OA
SJR Skoru0,261
H-Index29
YayıncıKafkas University
ÜlkeTurkey
Veterinary (miscellaneous) (Q3)
Dergi sayfasına git

Metrikler

5
Atıf
5
Yazar
6
Anahtar Kelime

Sistemimizdeki Yazarlar

GS
GONCA SÖNMEZ
Dr. Öğr. Üyesi

Hızlı Erişim

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