Scopus
YÖKSİS Eşleşti
Biological and in Silico Studies on the Benzimidazole-Based Compounds
Chemistry Africa · Temmuz 2024
YÖKSİS Kayıtları
Biological and in Silico Studies on the Benzimidazole-Based Compounds
Chemistry Africa · 2024 ESCI
ÖĞRETİM GÖREVLİSİ İREM BAYAR →
Makale Bilgileri
DergiChemistry Africa
Yayın TarihiTemmuz 2024
Cilt / Sayfa7 · 2345-2352
Scopus ID2-s2.0-85184174452
Özet
Two 1,2-disubstituted benzimidazole-based compounds (2 and 3) were synthesized in this study. The antiproliferative activities of these compounds 1-(4-methylbenzyl)-2-p-tolyl-1H-benzo[d]imidazole (2), 1-(3-methoxybenzyl)-2-p-tolyl-1H-benzo[d]imidazole (3) together with cisplatin as a positive control drug were performed by the MTT method against the MDA-MB-231 breast cancer cell line. Compound 2 exhibited relatively higher cytotoxic activity. Molecular docking studies of compounds were performed against five breast cancer targets (PARP5A, PARP1, Bcl-2, JAK2, CDK4). By interacting with these targets, effective amino acid residues and binding parameter values in the binding site were determined.
Yazarlar (3)
1
İrem Bayar
2
Burçin Türkmenoğlu
ORCID: 0000-0002-5770-0847
3
Senem Akkoc
ORCID: 0000-0002-1260-9425
Anahtar Kelimeler
Benzimidazole
Cytotoxic Activity
Molecular Docking
Kurumlar
Bahçeşehir Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Süleyman Demirel Üniversitesi
Isparta Turkey
University of Erzincan
Erzincan Turkey