Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Biological and in Silico Studies on the Benzimidazole-Based Compounds
Chemistry Africa · Temmuz 2024
YÖKSİS Kayıtları
Biological and in Silico Studies on the Benzimidazole-Based Compounds
Chemistry Africa · 2024 ESCI
Öğr. Gör. İREM BAYAR →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Biological and in Silico Studies on the Benzimidazole-Based Compounds
2024 ISSN: 2522-5758 ESCI
Öğr. Gör. İREM BAYAR →
Bioactive Compounds of Plantago arenaria and Their Efects on SH‑SY5Y Cells: Phenolic Content and Docking Analysis
2024 ISSN: 2522-5758 ESCI
Dr. Öğr. Üyesi GAMZE DEMİREL →
Makale Bilgileri
Dergi
Chemistry Africa
ISSN25225758
Yayın TarihiTemmuz 2024
Cilt / Sayfa7 · 2345-2352
Scopus ID2-s2.0-85184174452
Özet
Two 1,2-disubstituted benzimidazole-based compounds (2 and 3) were synthesized in this study. The antiproliferative activities of these compounds 1-(4-methylbenzyl)-2-p-tolyl-1H-benzo[d]imidazole (2), 1-(3-methoxybenzyl)-2-p-tolyl-1H-benzo[d]imidazole (3) together with cisplatin as a positive control drug were performed by the MTT method against the MDA-MB-231 breast cancer cell line. Compound 2 exhibited relatively higher cytotoxic activity. Molecular docking studies of compounds were performed against five breast cancer targets (PARP5A, PARP1, Bcl-2, JAK2, CDK4). By interacting with these targets, effective amino acid residues and binding parameter values in the binding site were determined.
Yazarlar (3)
1
İrem Bayar
2
Burçin Türkmenoğlu
ORCID: 0000-0002-5770-0847
3
Senem Akkoc
ORCID: 0000-0002-1260-9425
Anahtar Kelimeler
Benzimidazole
Cytotoxic Activity
Molecular Docking
Kurumlar
Bahçeşehir Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Süleyman Demirel Üniversitesi
Isparta Turkey
University of Erzincan
Erzincan Turkey
Scimago Dergi (ISSN Eşleşmesi)
Chemistry Africa
Q3
SJR Skoru0,401
H-Index33
YayıncıSpringer Science and Business Media Deutschland GmbH
ÜlkeGermany
Catalysis (Q3)
Chemistry (miscellaneous) (Q3)
Environmental Chemistry (Q3)
Physical and Theoretical Chemistry (Q3)
Metrikler
2
Atıf
3
Yazar
3
Anahtar Kelime