Scopus
YÖKSİS Eşleşti
Are owned dogs or stray dogs more prepared to diseases? A comparative study of immune system gene expression of perforin and granzymes
Acta Veterinaria Hungarica · Mart 2022
YÖKSİS Kayıtları
Are owned dogs or stray dogs more prepared to diseases? A comparative study of immune system gene expression of perforin and granzymes
Akademiai Kiado Zrt. · 2022 SCI-Expanded
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Makale Bilgileri
DergiActa Veterinaria Hungarica
Yayın TarihiMart 2022
Cilt / Sayfa70 · 24-29
Scopus ID2-s2.0-85127251522
Özet
Stray dogs are inevitably exposed to more infections than owned dogs living indoor. However, no studies have investigated whether the immune system gene expression differs between owned dogs kept in better care conditions and stray dogs living outside. To investigate this, blood samples were taken from 90 dogs (45 owned and 45 stray dogs) that were checked and confirmed as healthy. By using qPCR, the amples were analyzed for the expression of the perforin, granzyme A and granzyme B genes, which are associated with the activation of apoptotic pathways in the immune system. We found that the perforin and granzyme A gene expression levels were higher in stray dogs although the differences were not statistically significant. On the other hand, a 2.81 times higher and a notable difference (P < 0.001) was found in the expression level of granzyme B gene in stray dogs. These results indicate that the immune system in stray dogs might be more prepared for diseases than that of the owned dogs and the granzyme B gene plays a more dominant role in the immune response than granzyme A and perforin.
Yazarlar (2)
1
Mehmet Cevat Temizkan
2
Gonca Sönmez
Anahtar Kelimeler
canine
gene expression
granzyme
owned dog
perforin
stray dog
Kurumlar
Bozok Üniversitesi
Yozgat Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
3
Atıf
2
Yazar
6
Anahtar Kelime