Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Development and in vitro evaluation of temozolomide-loaded PLGA nanoparticles in a thermoreversible hydrogel system for local administration in glioblastoma multiforme
Journal of Drug Delivery Science and Technology · Haziran 2020
YÖKSİS Kayıtları
Development and in vitro evaluation of temozolomide-loaded PLGA nanoparticles in a thermoreversible hydrogel system for local administration in glioblastoma multiforme
Journal of Drug Delivery Science and Technology · 2020 SCI-Expanded
Dr. Öğr. Üyesi SEMA ARISOY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Development and in vitro evaluation of temozolomide-loaded PLGA nanoparticles in a thermoreversible hydrogel system for local administration in glioblastoma multiforme
2020 ISSN: 1773-2247 SCI-Expanded
Dr. Öğr. Üyesi SEMA ARISOY →
In-vivo evaluation of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers and mesenchymal stem cells in diabetic wound healing
2021 ISSN: 1773-2247 SSCI Q2
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds
2017 ISSN: 1773-2247 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Formulation and in vitro evaluation of topical nanoemulsion and nanoemulsion-based gels containing daidzein
2019 ISSN: 1773-2247 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Development and characterization of polymeric nanoparticles containing ondansetron hydrochloride as a hydrophilic drug
2022 ISSN: 1773-2247 SCI-Expanded Q2
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
2022 ISSN: 1773-2247 SCI-Expanded
Arş. Gör. TAMER TEKİN →
Preparation, characterization and evaluation of liposomal-freeze dried anthocyanin-enriched Vaccinium arctostaphylos L. fruit extract incorporated into fast dissolving oral films
2022 ISSN: 1773-2247 SCI-Expanded Q1
Prof. Dr. YÜKSEL KAN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
2022 ISSN: 1773-2247 SCI-Expanded
Prof. Dr. ZELİHA ESİN ÇELİK →
Preparation and evaluation of fast-dissolving albendazole sulfoxide and praziquantel-loaded polyvinylpyrrolidone nanofiber films by electrospinning
2024 ISSN: 1773-2247 SCI Q1
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Multifunctional hernia repair biopatch: Development, characterization, in vitro and in vivo evaluation
2024 ISSN: 1773-2247 SCI-Expanded Q1
Prof. Dr. MEHMET TUZCU →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded
Dr. Öğr. Üyesi ŞEYMA TETİK RAMA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Arş. Gör. KÜBRA YILMAZ →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Dr. Öğr. Üyesi HARUN YONAR →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Öğr. Gör. FATİH ÖZCAN →
Development of phytase targeted PLGA nanoparticles loaded with albendazole sulfoxide and praziquantel and evaluation of efficacy on the hydatid cysts
2025 ISSN: 1773-2247 SCI-Expanded Q1
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Makale Bilgileri
ISSN17732247
Yayın TarihiHaziran 2020
Cilt / Sayfa57
Scopus ID2-s2.0-85080110421
Özet
With its ability to cross the blood-brain barrier, temozolomide (TMZ) is the first-line treatment option in glioblastoma multiforme therapy. This study aims to design TMZ-loaded PLGA nanoparticles (TMZ-PLGA-NP) in a thermoreversible hydrogel system comprising Pluronic® F-127. TMZ-PLGA-NP were prepared via emulsion-solvent evaporation method using dimethylformamide (DMF) as organic solvent and PVA solution as stabilizer. Experimental parameters for the formulation process and in vitro release profiles of free drug, TMZ-PLGA-NP and TMZ-PLGA-NP-loaded in hydrogel were investigated. Particle size in the range of 100–200 nm with an encapsulation efficiency of 55–70% has been obtained. In vitro studies showed that the TMZ-PLGA-NP loaded in hydrogel formulations have significantly slowed down the release process, providing controlled and sustained release. These nanoparticles were efficiently taken up by the glioblastoma cells and the TMZ released from the TMZ-PLGA-NP-loaded in hydrogel could reach to the efficiency of direct exposure to the free-drug. In conclusion, the thermoreversible hydrogel system containing TMZ-loaded PLGA nanoparticles may serve as a promising approach that could sustain long-term drug release for the treatment of residual glial tumors after surgery.
Yazarlar (5)
1
Ozgun Sayiner
2
Sema Arisoy
ORCID: 0000-0003-2798-1884
3
Tansel Comoglu
ORCID: 0000-0002-4221-5814
4
Feyza Gul Ozbay
5
Gunes Esendagli
Anahtar Kelimeler
Brain delivery
Glioblastoma multiforme
Hydrogel
Nanoparticle
Temozolomide
Thermoreversible
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Inönü Üniversitesi
Malatya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Drug Delivery Science and Technology
Q1
SJR Skoru0,817
H-Index89
YayıncıEditions de Sante
ÜlkeFrance
Pharmaceutical Science (Q1)
Metrikler
37
Atıf
5
Yazar
6
Anahtar Kelime