Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
The evaluation of clinicopathological and immunohistochemical findings of cervical clear cell carcinoma in a bitch
Acta Scientiae Veterinariae · Ocak 2018
YÖKSİS Kayıtları
The Evaluation of Clinicopathological and Immunohistochemical Findings of Cervical Clear Cell Carcinoma in a Bitch
Acta Scientiae Veterinariae · 2018 SCI-Expanded
Doç. Dr. HASAN ALKAN →
The Evaluation of Clinicopathological and Immunohistochemical Findings of Cervical Clear Cell Carcinoma in a Bitch
Acta Scientiae Veterinariae · 2018 SCI-Expanded
Doç. Dr. KÜBRA KARAKAŞ ALKAN →
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Effect of CorynebacteriumcutisLysate on Serum Oxidative Stressand Plasma Prostaglandin F2 Metabolite Levels
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Hepatoprotective Effects of Ginseng in Rats Fed Cholesterol Rich Diet
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Detection of Antibodies against Equine Herpes Virus 1and Equine Herpes Virus 4 in Horses in Southeast Anatolia by Indirect Elisa
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Hepatoprotective Effects of Ginseng in Rats Fed Cholesterol Rich Diet
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Investigation of the Effect of Tarantula cubensis Extract on Acute Phase Response
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Effect of Anti TNF-a on the Development of Offspringand Pregnancy Loss During Pregnancy in Rats
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Amiodarone May Prevent the Tilmicosin caused Lethal Toxicity
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Effect of Hoof Trimming on Milk Yield in Dairy Cows with Foot Disease
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Bovine coronavirus (BoCV) infection in calves with diarrhoea and their dams
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The Effects of Coenzyme Q10 on Inflammation Markers in Streptozotocin-Induced Diabetic Rats
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The Effects of Coenzyme Q10 on Inflammation Markersin Streptozotocin-Induced Diabetic Rats
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Comparison of the Effectiveness of Halofuginone Lactate and Paromomycin in the Treatment of Calves Naturally Infected with Cryptosporidium parvum
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Safety of antitheilerial drug buparvaquone in rams
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Pentoxifylline May Restore Kanamycin-Induced Renal Damage in Rats
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Comparison of the Effectiveness of Halofuginone Lactate and Paromomycin in the Treatment of Calves Naturally Infected with Cryptosporidium parvum
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Comparison of Thermographic Imaging and Other Diagnostic Techniques in Diagnosis of Cattle with Laminitis
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Bovine Coronavirus (BoCV) Infection in Calves with Diarrhoea and Their Dams
2018 ISSN: 1678-0345 SCI-Expanded
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Makale Bilgileri
ISSN16780345
Yayın TarihiOcak 2018
Cilt / Sayfa46
Scopus ID2-s2.0-85077597611
Erişim🔓 Açık Erişim
Özet
Background: Clear cell carcinoma (CCC) of the cervix is a rarely seen malignant tumor which is classified in adenocarcinomas of the endometrium. It is responsible for 2.15-3.0% of endometrial tumors. The diagnosis is difficult and is still controversial in uterine carcinomas. Macroscopically, masses were protruding to endometrial surface. However, the definitive diagnosis was carried by microscopical evaluation. The cells contain clear cytoplasm. The cells are seen in this pattern because there is either glycogenation or secretoric activity in the cells. Case: In the present case, clinicopathologic and immunohistochemical findings of clear cell carcinoma of the cervix were defined in a 3 year-old spayed Golden retriever bitch. Previously spayed bitch, which had vaginal discharge for the last month-long, was submitted to the Department of Obstetrics and Gynecology, Ankara University, Faculty of Veterinary Medicine. In the general clinical examination, vaginoscopy was performed and vaginal cytology was obtained from smear. The source of discharge was detected as cervix uteri. In vaginal cytologic examination, erythrocyte, neutrophile and superficial cells were observed. In abdominal ultrasonography, a hypoechoic mass was detected at cranial part of the urinary bladder. To evaluate the general health condition of the dog, total blood counting and serum biochemistry were analyzed in addition to assessing its hormone prophlye. Estrogen and progesterone levels were evaluated. Estradiol (E2) level was measured as 23 pg/mL and progesterone level was measured as 1.96 ng/mL from collected serum. The cervical mass in diameters of 3x4x2.5 cm was removed in operation. In macroscopical examination, it had spherical and regularly shape. After the macroscopical examination, tissue samples were fixed in 10% buffered formalin. Then, the samples stained with Haematoxylin-Eosin (H&E), Masson's trichrome and PAS stainings, respectively. At the macroscopic and histological examinations, the mass was diagnosed as clear cell carcinoma. Immunohistochemically, the tumor was stained with CK19 -SMA, vimentin, desmin, TGF-, VEGF, CEA, ER and PR markers. Other markers gave moderate to severe reactions in exception for no or weak ER and PR positivities. In direction of these results, clear cell carcinoma of cervix had been found remarkably due to first description in a spayed bitch on the basis of knowledge. Discussion: Clear cell carcinoma (CCC) is one type of the endometrial carcinomas. It is frequently known to have aggressive behavior and unfavorable prognosis. In human counterparts, clear cell carcinoma is frequently reoccurred in caudoabdominal and pelvic region even after being removed. The occurrence of clear cell carcinoma has highly increased with diethylstilbestrol usage during pregnancy. The situation on uterine carcinoma is nearly same in domestic animals. It is related to prolonged estrogenism. In this case, the bitch has been under prolong exposure to estrogenic effect. Indeed the estradiol level was high when compared to spayed female. Also, it is thought that the reason of high estradiol level does not depend on the ovarian remnant. It is believed this situation may be relevant to exogen hormone usage. Vaginal smear confirmed erythrocyte (due to bleeding), predominantly superficial cells to it's under estrogenic effect even despite being spayed.
Yazarlar (3)
1
Kubra Karakas-Alkan
ORCID: 0000-0001-9177-9299
2
Mehmet Eray Alcigir
3
Hasan Alkan
ORCID: 0000-0001-8332-5334
Anahtar Kelimeler
Bitch
Cervix
Clear cell carcinoma
Clinicopathology
Marker
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Acta Scientiae Veterinariae
Q4
SJR Skoru0,155
H-Index20
YayıncıUniversidade Federal do Rio Grande do Sul
ÜlkeBrazil
Veterinary (miscellaneous) (Q4)