Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q1
Aglepristone and cloprostenol combination in the termination of late-term pregnancy in queens
Journal of Feline Medicine and Surgery · Ekim 2020
YÖKSİS Kayıtları
Aglepristone and cloprostenol combination in the termination of late-term pregnancy in queens
JOURNAL OF FELINE MEDICINE AND SURGERY · 2020 SCI-Expanded
Doç. Dr. HASAN ALKAN →
Aglepristone and cloprostenol combination in the termination of late-term pregnancy in queens
Journal of Feline Medicine and Surgery · 2020 SCI-Expanded
Doç. Dr. KÜBRA KARAKAŞ ALKAN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Aglepristone and cloprostenol combination in the termination of late-term pregnancy in queens
2020 ISSN: 1098-612X SCI-Expanded
Doç. Dr. HASAN ALKAN →
Makale Bilgileri
ISSN1098612X
Yayın TarihiEkim 2020
Cilt / Sayfa22 · 907-915
Scopus ID2-s2.0-85077227762
Erişim🔓 Açık Erişim
Özet
Objectives: Termination rates for the highly recommended aglepristone (AGL) treatment are low in late-term pregnancy in queens. We studied the effects of an AGL and cloprostenol (CLO) combination in the termination of late-term pregnancy. Methods: Pregnant queens were assigned to two groups. Queens in the AGL group (n = 10) received AGL 10 mg/kg, twice, 24 h apart. Queens in the AGL-CLO group (n = 9) were additionally injected with a single dose of CLO (5 μg/kg) 24 h after the second dose of AGL. Progesterone, 17beta(β)-oestradiol, cortisol, oxytocin and prostaglandin F2alpha (PGF2α) metabolite were measured in sera obtained at days 0, 1 and 2, and on the day of abortion. Results: Average gestational age in both groups was similar (AGL 38.61 ± 0.91 days vs AGL-CLO 39.39 ± 1.35 days; P >0.05). Termination rates were 80% and 100% in the AGL and AGL-CLO groups, respectively (P <0.05). Fetal expulsion time was significantly longer (P <0.001) in the AGL group (96.9 ± 6 h) compared with the AGL-CLO group (69.8 ± 3.3 h). Duration of abortion was 19.8 ± 2.6 h and 12.6 ± 1.4 h in the AGL and AGL-CLO groups, respectively (P <0.05). Both treatments were well tolerated. Significantly (P <0.05) lower serum progesterone concentrations were observed in both groups at the day of abortion and concentrations in the AGL-CLO group (4.19 ± 0.80 ng/ml) were lower than in the AGL group (9.89 ± 2.21 ng/ml; P <0.05). Conclusions and relevance: AGL and CLO combination increases pregnancy termination rate in late-term pregnant queens. In addition, CLO contributes to a decrease in luteal function in AGL-treated late-term pregnant queens.
Yazarlar (4)
1
Kubra Karakas-Alkan
ORCID: 0000-0001-9177-9299
2
Hasan Alkan
ORCID: 0000-0001-8332-5334
3
Gizem Tez
4
Halit Kanca
Anahtar Kelimeler
Aglepristone
cloprostenol
pregnancy termination
progesterone
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Feline Medicine and Surgery
Q1
OA
SJR Skoru0,894
H-Index88
YayıncıSAGE Publications Inc.
ÜlkeUnited Kingdom
Small Animals (Q1)
Metrikler
3
Atıf
4
Yazar
4
Anahtar Kelime