Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Aglepristone and cloprostenol combination in the termination of late-term pregnancy in queens
Journal of Feline Medicine and Surgery · Ekim 2020
YÖKSİS Kayıtları
Aglepristone and cloprostenol combination in the termination of late-term pregnancy in queens
JOURNAL OF FELINE MEDICINE AND SURGERY · 2020 SCI-Expanded
DOÇENT HASAN ALKAN →
Aglepristone and cloprostenol combination in the termination of late-term pregnancy in queens
Journal of Feline Medicine and Surgery · 2020 SCI-Expanded
DOÇENT KÜBRA KARAKAŞ ALKAN →
Makale Bilgileri
DergiJournal of Feline Medicine and Surgery
Yayın TarihiEkim 2020
Cilt / Sayfa22 · 907-915
Scopus ID2-s2.0-85077227762
Erişim🔓 Açık Erişim
Özet
Objectives: Termination rates for the highly recommended aglepristone (AGL) treatment are low in late-term pregnancy in queens. We studied the effects of an AGL and cloprostenol (CLO) combination in the termination of late-term pregnancy. Methods: Pregnant queens were assigned to two groups. Queens in the AGL group (n = 10) received AGL 10 mg/kg, twice, 24 h apart. Queens in the AGL-CLO group (n = 9) were additionally injected with a single dose of CLO (5 μg/kg) 24 h after the second dose of AGL. Progesterone, 17beta(β)-oestradiol, cortisol, oxytocin and prostaglandin F2alpha (PGF2α) metabolite were measured in sera obtained at days 0, 1 and 2, and on the day of abortion. Results: Average gestational age in both groups was similar (AGL 38.61 ± 0.91 days vs AGL-CLO 39.39 ± 1.35 days; P >0.05). Termination rates were 80% and 100% in the AGL and AGL-CLO groups, respectively (P <0.05). Fetal expulsion time was significantly longer (P <0.001) in the AGL group (96.9 ± 6 h) compared with the AGL-CLO group (69.8 ± 3.3 h). Duration of abortion was 19.8 ± 2.6 h and 12.6 ± 1.4 h in the AGL and AGL-CLO groups, respectively (P <0.05). Both treatments were well tolerated. Significantly (P <0.05) lower serum progesterone concentrations were observed in both groups at the day of abortion and concentrations in the AGL-CLO group (4.19 ± 0.80 ng/ml) were lower than in the AGL group (9.89 ± 2.21 ng/ml; P <0.05). Conclusions and relevance: AGL and CLO combination increases pregnancy termination rate in late-term pregnant queens. In addition, CLO contributes to a decrease in luteal function in AGL-treated late-term pregnant queens.
Yazarlar (4)
1
Kubra Karakas-Alkan
ORCID: 0000-0001-9177-9299
2
Hasan Alkan
ORCID: 0000-0001-8332-5334
3
Gizem Tez
4
Halit Kanca
Anahtar Kelimeler
Aglepristone
cloprostenol
pregnancy termination
progesterone
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
4
Yazar
4
Anahtar Kelime