Scopus
YÖKSİS Eşleşti
Live in same region, respond differently: Canine and human response to pollutants in placental accumulation
Chemosphere · Ağustos 2022
YÖKSİS Kayıtları
Live in same region, respond differently: Canine and human response to pollutants in placental accumulation
Chemosphere · 2022 SCI-Expanded
DOÇENT KÜBRA KARAKAŞ ALKAN →
Makale Bilgileri
DergiChemosphere
Yayın TarihiAğustos 2022
Cilt / Sayfa301
Scopus ID2-s2.0-85129222991
Özet
Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons (PAHs) are endocrine-disrupting chemicals (EDCs). Their presence in the environment is particularly concerning in cases of fetal exposure, which is the most vulnerable period of life for both human and animals who share the same environment. Placenta, as a sample collected using noninvasive methods to screen EDCs, is a good indicator for potential fetal exposure. Although recent studies indicate that companion animal may correspond to human exposure, species-specific anatomo-morphological and metabolic differences are controversial. In this study, placenta samples of 60 women and 25 dogs living and giving birth within the same region were evaluated for the presence of PCB, OCP, PBDE, and PAH residues; where, socio-demographic factors were also assessed to identify the possible sources. Gas chromatography-mass spectrometry method was validated for the matrix, and among 45 screened and targeted pollutants, only 18 were found in human placentas. While the most frequently detected pollutants were DDTs, followed by PAHs and PCBs in decreasing order, the pollutants with the highest concentrations were PAHs, followed by PCBs and DDTs. Only five of the target contaminants were detected in the dog placentas. These results indicate that; as dogs have different bioaccumulation capacities and higher excretion rates than humans, the life-long effects of exposure to endocrine compound and possible consequences related to adverse health outcomes are expected to vary and concentrations cannot be directly correlated.
Yazarlar (9)
1
Begum Yurdakok-Dikmen
ORCID: 0000-0002-0385-3602
2
Ozgur Kuzukiran
ORCID: 0000-0001-9294-2801
3
Recep Uyar
ORCID: 0000-0002-7788-6685
4
Ummu Gulsum Boztepe
ORCID: 0000-0002-9277-6310
5
Hasan Tolga Çelik
ORCID: 0000-0002-1725-0722
6
Ozgur Ozyuncu
7
Yagmur Turgut
ORCID: 0000-0002-8918-3135
8
Halit Kanca
9
Kubra Karakas-Alkan
ORCID: 0000-0001-9177-9299
Anahtar Kelimeler
Endocrine disruptor
Persistent organic pollutants
Placenta
Sentinel
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Çankiri Karatekin Üniversitesi
Cankiri Turkey
Hacettepe Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
5
Atıf
9
Yazar
4
Anahtar Kelime