Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Transcriptomic evaluation of metals detected in placenta
Chemosphere · Eylül 2024
YÖKSİS Kayıtları
Transcriptomic evaluation of metals detected in placenta
Chemosphere · 2024 SCI-Expanded
Doç. Dr. KÜBRA KARAKAŞ ALKAN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Some organochlorine pesticide residues in fish species in Konya Turkey
2009 ISSN: 00456535 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Transcriptomic analysis of boron hyperaccumulation mechanisms in Puccinellia distans
2018 ISSN: 0045-6535 SCI-Expanded Q1
Prof. Dr. MEHMET BABAOĞLU →
Evaluation of occurrence, fate and removal of priority phthalate esters (PAEs) in wastewater and sewage sludge by advanced biological treatment, waste stabilization pond and constructed wetland
2022 ISSN: 0045-6535 SCI-Expanded Q1
Prof. Dr. MERYEM KARA →
Live in same region, respond differently: Canine and human response to pollutants in placental accumulation
2022 ISSN: 0045-6535 SCI-Expanded Q1
Doç. Dr. KÜBRA KARAKAŞ ALKAN →
Fe2O3-modified graphene oxide mitigates nanoplastic toxicity via regulating gas exchange, photosynthesis, and antioxidant system in Triticum aestivum
2022 ISSN: 0045-6535 SCI-Expanded Q1
Doç. Dr. BÜŞRA ARIKAN ABDULVELİ →
Fe2O3-modified graphene oxide mitigates nanoplastic toxicity via regulating gas exchange, photosynthesis, and antioxidant system in Triticum aestivum
2022 ISSN: 0045-6535 SCI-Expanded Q1
Prof. Dr. EVREN YILDIZTUGAY →
Fe2O3-modified graphene oxide mitigates nanoplastic toxicity via regulating gas exchange, photosynthesis, and antioxidant system in Triticum aestivum
2022 ISSN: 0045-6535 SCI-Expanded Q1
Prof. Dr. HALİT ÇAVUŞOĞLU →
Evaluation of occurrence, fate and removal of priority phthalate esters (PAEs) in wastewater and sewage sludge by advanced biological treatment, waste stabilization pond and constructed wetland
2022 ISSN: 0045-6535 SCI-Expanded Q1
Doç. Dr. SALİHA DİNÇ →
The characterization of plant derived-carbon dots and its responses on chlorophyll a fluorescence kinetics, radical accumulation in guard cells, cellular redox state and antioxidant system in chromium stressed-Lactuca sativa
2024 ISSN: 0045-6535 Scopus
Doç. Dr. BÜŞRA ARIKAN ABDULVELİ →
Exploring the defense strategies of benzalkonium chloride exposures on the antioxidant system, photosynthesis and ROS accumulation in Lemna minor
2024 ISSN: 0045-6535 SCI Q1
Prof. Dr. EVREN YILDIZTUGAY →
The characterization of plant derived-carbon dots and its responses on chlorophyll a fluorescence kinetics, radical accumulation in guard cells, cellular redox state and antioxidant system in chromium stressed-Lactuca sativa
2024 ISSN: 0045-6535 Scopus
Doç. Dr. CANAN BAŞLAK →
Transcriptomic evaluation of metals detected in placenta
2024 ISSN: 0045-6535 SCI-Expanded Q1
Doç. Dr. KÜBRA KARAKAŞ ALKAN →
Exploring the defense strategies of benzalkonium chloride exposures on the antioxidant system, photosynthesis and ROS accumulation in Lemna minor
2024 ISSN: 0045-6535 SCI-Expanded Q1
Doç. Dr. İSMAİL TARHAN →
Exploring the defense strategies of benzalkonium chloride exposures on the antioxidant system, photosynthesis and ROS accumulation in Lemna minor
2024 ISSN: 0045-6535 Scopus
Doç. Dr. BÜŞRA ARIKAN ABDULVELİ →
Makale Bilgileri
Dergi
Chemosphere
ISSN00456535
Yayın TarihiEylül 2024
Cilt / Sayfa363
Scopus ID2-s2.0-85199986577
Özet
This research aims to assess the concentration of metals in human and canine placentas from the same geographic area and to investigate how these metal levels influence gene expression within the placenta. Placentas of 25 dogs and 60 women who had recently given birth residing in Ankara, Turkey were collected and subjected to metal analysis using ICP-OES. Placentas with detectable metal levels underwent further examination including Next Generation Sequencing, transcriptional analysis, single nucleotide polymorphism investigation, and extensive scrutiny across various groups. For women, placentas with concurrent detection of aluminum (Al), lead (Pb), and cadmium (Cd) underwent transcriptomic analysis based on metal analysis results. However, the metal load in dog placentas was insufficient for comparison. Paired-end sequencing with 100-base pair read lengths was conducted using the DNBseq platform. Sequencing quality control was evaluated using FastQC, fastq screen, and MultiQC. RNA-sequencing data is publicly available via PRJNA936158. Comparative analyses were performed between samples with detected metals and “golden” samples devoid of these metals, revealing significant gene lists and read counts. Normalization of read counts was based on estimated size factors. Principal Component Analysis (PCA) was applied to all genes using rlog-transformed count data. Results indicate that metal exposure significantly influences placental gene expression, impacting various biological processes and pathways, notably those related to protein synthesis, immune responses, and cellular structure. Upregulation of immune-related pathways and alterations in protein synthesis machinery suggest potential defense mechanisms against metal toxicity. Nonetheless, these changes may adversely affect placental function and fetal health, emphasizing the importance of monitoring and mitigating environmental exposure to metals during pregnancy.
Yazarlar (12)
1
Ozgur Kuzukiran
ORCID: 0000-0001-9294-2801
2
Begum Yurdakok-Dikmen
ORCID: 0000-0002-0385-3602
3
Recep Uyar
ORCID: 0000-0002-7788-6685
4
Yagmur Turgut-Birer
ORCID: 0000-0002-8918-3135
5
Hasan Tolga Çelik
ORCID: 0000-0002-1725-0722
6
Ilker Simsek
ORCID: 0000-0001-9181-9879
7
Kubra Karakas Alkan
8
Ummu Gulsum Boztepe
ORCID: 0000-0002-9277-6310
9
Ozgur Ozyuncu
10
Halit Kanca
11
Hilal Ozdag
ORCID: 0000-0001-7940-2499
12
Ayhan Filazi
ORCID: 0000-0002-2800-6215
Anahtar Kelimeler
Dog
Genes
Human
Metal
One health
Placenta
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Çankiri Karatekin Üniversitesi
Cankiri Turkey
Hacettepe Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Chemosphere
Q1
SJR Skoru1,648
H-Index353
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Chemistry (miscellaneous) (Q1)
Environmental Chemistry (Q1)
Environmental Engineering (Q1)
Health, Toxicology and Mutagenesis (Q1)
Medicine (miscellaneous) (Q1)
Pollution (Q1)
Public Health, Environmental and Occupational Health (Q1)
Metrikler
3
Atıf
12
Yazar
6
Anahtar Kelime