Scopus
Immobilised lipase applications in health
International Journal of Pharmaceutics · Mart 2026
Makale Bilgileri
DergiInternational Journal of Pharmaceutics
Yayın TarihiMart 2026
Cilt / Sayfa693
Scopus ID2-s2.0-105030882490
Özet
Immobilized lipase is widely used in biocatalysis, yet its potential in health remains underexplored. This review evaluates health‑oriented applications of lipase immobilization, including advanced oral enzyme replacement systems for exocrine pancreatic insufficiency, co‑immobilisation with probiotics to modulate gut ecology, and extracorporeal or implantable lipid‑removal devices for acute dyslipidemia. Diagnostic applications in lipid biosensors, localized activation of ester‑based prodrugs, and the enzymatic production of structured lipids for medical nutrition such as human‑milk‑fat mimetics and tailored triacylglycerols are also discussed. We emphasize how support materials and immobilization strategies govern catalytic activity, regiospecificity, stability and biocompatibility, and outline key translational challenges, including in‑vivo validation, immune responses, process economics and regulatory issues.
Yazarlar (2)
1
Merve İnel
2
Elif Ozyilmaz
Anahtar Kelimeler
Enzyme replacement
Immobilized lipase
Prodrug activation
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey