Scopus
Exploring manganese-loaded nanoparticle formulations as contrast agents: A comprehensive in vitro and in vivo study
Journal of Pharmaceutical Sciences · Mayıs 2026
Makale Bilgileri
DergiJournal of Pharmaceutical Sciences
Yayın TarihiMayıs 2026
Cilt / Sayfa115
Scopus ID2-s2.0-105032552418
Özet
Magnetic Resonance Imaging (MRI) is a crucial diagnostic modality in modern medical practice, offering non-invasive insight into internal structures and functions of the human body. The development of MRI contrast agents has significantly improved imaging sensitivity and precision. Traditional gadolinium-based agents, while effective, have been linked to nephrogenic systemic fibrosis (NSF), necessitating the exploration of alternative contrast agents. Nanoparticle-based systems have emerged as promising candidates for new contrast media, leveraging the unique properties of nanoparticles to address technological and medical challenges. Manganese has garnered attention due to its potential as a safe and effective alternative to gadolinium-based agents. This study delves into the synthesis of manganese loaded nanoparticles using poly (lactic-co-glycolic acid) (PLGA), a biodegradable polymer with proven biocompatibility. Two distinct manganese nanoencapsulation methods were devised and evaluated for their toxicity profiles. The method demonstrating superior biocompatibility, designated as PLGA-MN, was selected for in vivo assessments. Comparative analysis was performed against a control group administered manganese acetate (MnAc) (PBS) solution. In vivo MR imaging was performed on Sprague-Dawley rats, while the distribution of PLGA-MNs in blood, brain, liver, and spleen was determined through inductively coupled plasma mass spectrometry (ICP-MS). The results lay the foundation for advancing contrast agent development, harnessing nanotechnology to elevate diagnostic imaging capabilities and simultaneously addressing the safety considerations linked to conventional agents such as gadolinium.
Yazarlar (9)
1
Maide Öztürk Dalkılınç
2
Melih Zeki Kaya
ORCID: 0000-0002-2874-6037
3
Meltem Karataş
4
Yakup Gultekin
5
Tuğba Çopur
6
İmran Vural
7
Levent Öner
ORCID: 0000-0002-6510-7680
8
Kader Karlı Oğuz
9
Sibel Bozdağ Pehlivan
Anahtar Kelimeler
Contrast agent
Lipid nanoparticle
Manganese
Polymeric nanoparticle
Kurumlar
Bilkent Üniversitesi
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey