Scopus
🔓 Açık Erişim
Novel 3D-printed polycaprolactone/gelatin based biopatches loaded with natural antibacterial agents for hernia treatment
Biomedical Materials Bristol England · Mart 2026
Makale Bilgileri
DergiBiomedical Materials Bristol England
Yayın TarihiMart 2026
Cilt / Sayfa21
Scopus ID2-s2.0-105031861946
Erişim🔓 Açık Erişim
Özet
Incisional hernia is a common postoperative complication, particularly following abdominal surgeries, and is frequently associated with recurrence and impaired healing due to postoperative infections. In this study, a dual-layered hernia repair biopatch was developed by integrating a 3D-printed polycaprolactone/gelatin (PCL/Ge) scaffold, providing mechanical support, with an electrospun nanofibrous layer composed of PCL/Ge/κ-carrageenan (κ-C) to promote wound healing. To impart antimicrobial functionality, the scaffolds were functionalized with eitherAgrimonia eupatoria(AE) extract or the clinically used antibiotic rifampicin (RIF). Commercial polypropylene (PP) meshes were employed as control groups in bothin vitroandin vivoevaluations. Mechanical testing demonstrated that the developed biopatches exhibited tensile strengths within a clinically relevant range, with values of 5.13 MPa and 2.49 MPa for the 3D-printed RIF-loaded and AE-loaded electrospun-coated scaffolds, respectively. Both AE- and RIF-loaded groups showed pronounced antibacterial activity againstS. aureus, a predominant pathogen associated with surgical site infections. Sustained and controlled release profiles were observed over 160 h, with cumulative release values of approximately 30%-35%.In vivoevaluation using a rat incisional hernia model revealed that AE exhibits strong potential as an alternative to conventional antibiotics, attributable to its phenolic-rich composition and associated anti-inflammatory and tissue-remodeling properties. Overall, these findings demonstrate that the proposed dual-layer biopatch, which integrates mechanical reinforcement with sustained antimicrobial activity, represents a promising and effective strategy for infection-resistant incisional hernia repair.
Yazarlar (18)
1
Ebru Uysal
2
Gozde Enguven
ORCID: 0009-0008-6096-3470
3
Hasan Ege
4
Mehmet Zeki Deveci
ORCID: 0000-0002-9532-247X
5
Fulya Dal Yontem
ORCID: 0000-0003-4767-083X
6
Gokhan Agturk
7
Savas Evran
8
Ibrahim Alakus
ORCID: 0000-0002-2031-7035
9
Omer Kirgiz
10
G. Akcakavak
11
Filiz Kazak Akcakavak
ORCID: 0000-0002-9065-394X
12
Halil Alakus
ORCID: 0000-0001-9265-2310
13
Cafer Tayer Isler
ORCID: 0000-0002-1910-8316
14
Mehmet Tuzcu
15
Muhammed Enes Altug
16
Oguzhan Gunduz
17
Cem Bulent Ustundag
ORCID: 0000-0002-4439-0878
18
Zeynep Ruya Ege
ORCID: 0009-0005-5725-7768
Anahtar Kelimeler
3D printing
Agrimonia eupatoria
antibacterial
hernia repair
polycaprolactone
rifampicin
tissue regeneration
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Haliç Üniversitesi
Istanbul Turkey
Health Biotechnology Joint Research and Application Center of Excellence
Istanbul Turkey
İstanbul Arel Üniversitesi
Istanbul Turkey
Koç Üniversitesi
Istanbul Turkey
Marmara Üniversitesi
Istanbul Turkey
Mustafa Kemal Üniversitesi
Antakya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Yıldız Teknik Üniversitesi
Istanbul Turkey