Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q1
Acotiamide Can Be Used as an Anti-Cognitive Disorder Agent in Diseases Associated with Cognitive Dysfunction
Pakistan Veterinary Journal · Ocak 2026
YÖKSİS Kayıtları
Acotiamide Can Be Used as an Anti-Cognitive Disorder Agent in Diseases Associated with Cognitive Dysfunction
Pakistan Veterinary Journal · 2026 SCI-Expanded
Dr. Öğr. Üyesi GONCA SÖNMEZ →
Acotiamide Can Be Used as an Anti-Cognitive Disorder Agent in Diseases Associated with
Cognitive Dysfunction
pakistan veterinary journal · 2026 SCI-Expanded
Arş. Gör. MUHAMMED HÜDAİ ÇULHA →
Acotiamide Can Be Used as an Anti-Cognitive Disorder Agent in Diseases Associated with Cognitive Dysfunction
Pakistan Veterinary Journal · 2026 SCI-Expanded
Prof. Dr. BURAK DİK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Clinical Comparison of Medetomidine with Isoflurane or Sevoflurane for Anesthesia in Horses
2015 ISSN: 0253-8318 SSCI
Prof. Dr. MUSTAFA ARICAN →
Bacillus anthracis isolated from a dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
A Retrospective Study of Fractures in Neonatal Calves 181 Cases 2002 2012
2013 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. KURTULUŞ PARLAK →
Effect of Different Storage Temperatures on the Stability of Bovine Viral Diarrhea Virus BVDV RNA in Blood Samples
2015 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. IRMAK DİK →
The investigation of bovine viral diarrhoea virus antigens with immunofluorescence and immunohistochemical methods in bovine abortions
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Effect of different storage temperatures on the stability of bovine viral diarrhea virus RNA in blood samples
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ATİLLA ŞİMŞEK →
Effect of Different Storage Temperatures on the Stability of Bovine Viral Diarrhea Virus BVDV RNA in Blood Samples
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. SİBEL YAVRU →
Bacillus anthracis Isolated from a Dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. OSMAN ERGANİŞ →
Bacillus anthracis Isolated from a Dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Doç. Dr. ASLI BALEVİ →
Genotypic Characterization of Bordetella bronchiseptica Strains Isolated from Stray and PetDogs
2016 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. UÇKUN SAİT UÇAN →
Quantification of mitral regurgitation in Anatolian Shepherd Dogs with aseymtomatic degenerative mitral valve disease
2016 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. HASAN GÜZELBEKTEŞ →
Genotypic Characterization of Bordetella bronchiseptica Strains Isolated from Stray and Pet Dogs
2016 ISSN: 0253-8318 SCI-Expanded
Doç. Dr. ASLI BALEVİ →
In Vitro Activity of Toxin Binders on Aflatoxin B1 in Poultry Gastrointestinal Medium
2018 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. HALİS UĞUZ →
Digit Bones (Acropodium) of Gazella (Gazella subgutturosa); Three-Dimensional Modelling
and Morphometry
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. MUSTAFA ORHUN DAYAN →
Predominancy of Rhipicephalus turanicus in Tick-infested Sheep from Turkey: a Large-scale Survey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. ALİ USLU →
Serological Investigation of Some Vector-Borne Parasitic and Rickettsial Agents in Dogs in the Western Part of Turkey
2021 ISSN: 0253-8318 SCI-Expanded Q1
Doç. Dr. ALİ USLU →
Serological Investigation of Some Vector-Borne Parasitic and Rickettsial Agents in Dogs in the Western Part of Turkey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. FERDA SEVİNÇ →
Predominancy of Rhipicephalus turanicus in Tick-infested Sheep from Turkey: a Large-scale Survey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. FERDA SEVİNÇ →
Digit Bones (Acropodium) of Gazella (Gazella subgutturosa); Three-Dimensional Modelling and Morphometry
2021 ISSN: 0253-8318 SCI-Expanded Q3
Dr. Öğr. Üyesi SEDAT AYDOĞDU →
Makale Bilgileri
ISSN02538318
Yayın TarihiOcak 2026
Cilt / Sayfa46 · 97-105
Scopus ID2-s2.0-105030671913
Erişim🔓 Açık Erişim
Özet
The steady increase in average lifespan of humans and animals has made the problem of aging-related cognitive impairment a significant issue. Alzheimer's disease (AD) in humans is a degenerative brain disease characterized by the loss of basic body functions due to neuronal damage, and canine cognitive dysfunction observed in dogs is stated to resemble human AD. Acetylcholine esterase (AChE) plays a role in the pathogenesis of the disease, and its inhibition prevents AChE-induced Aβ aggregation. Other pathological factors, including oxidative stress, inflammation and the Wnt pathway, also contribute to AD pathogenesis. The use of AChE inhibitor (AChEI) is the most effective way among the several available options for improving cholinergic symptoms. Although acotiamide is an AChEI, there is currently no information regarding its use in AD; therefore, this study aimed to examine the effects of acotiamide in an AD model for the first time. A total of 26 mice were divided into 4 groups: control, sham, Alzheimer and Alzheimer+Acotiamide. To create an experimental AD model, streptozotocin was administered intracerebroventricularly. In addition, acotiamide was administered intraperitoneally to the animals in the Alzheimer+Acotiamide group. The study evaluated AChE, choline acetyltransferase, β-secretase (BACE1), tumor necrosis factor-alpha, interleukin-10, α7nicotinic acetylcholine receptor, glycogen synthase kinase3beta, 8-hydroxy-2-deoxyguanosine and glutathione parameters; along with the number of neurons in the CA1 and CA3 regions, and the thickness in these areas. It can be concluded from results that acotiamide could prevent neuroinflammation, reduce AChE and BACE1 protein levels and may be effective in the treatment/prevention of AD.
Yazarlar (9)
1
Öznur Tufan Akarslan
2
Mehmet Burak Ates
ORCID: 0000-0003-1297-426X
3
Gonca Sönmez
4
O. Ozdemir
5
Burak Dik
6
M. Hüdai Çulha
7
Taha Hakan Uysal
8
H. Oǧuz
9
A. Er
Anahtar Kelimeler
Acotiamide
Alzheimer
Cognitive dysfunction
Inflammation
Mice
Treatment
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Pakistan Veterinary Journal
Q1
OA
SJR Skoru0,845
H-Index44
YayıncıUniversity of Agriculture
ÜlkePakistan
Veterinary (miscellaneous) (Q1)