Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
Central Sensitization Drives Symptom Burden in Microvascular Angina: A Cross-Sectional Case-Control Study
Turk Kardiyoloji Dernegi Arsivi · Mart 2026
YÖKSİS Kayıtları
Central Sensitization Drives Symptom Burden in Microvascular Angina: A Cross-Sectional Case-Control Study
Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology · 2026 TR DİZİN
Dr. Öğr. Üyesi HÜSEYİN TEZCAN →
Central Sensitization Drives Symptom Burden in Microvascular Angina: A Cross-Sectional Case-Control Study.
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir · 2025 TR DİZİN
Dr. Öğr. Üyesi HÜSEYİN TEZCAN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Central Sensitization Drives Symptom Burden in Microvascular Angina: A Cross-Sectional Case-Control Study
2026 ISSN: 1016-5169 TR DİZİN
Dr. Öğr. Üyesi HÜSEYİN TEZCAN →
Can atorvastatin calcium cause asymptomatic hypercalcemia
2014 ISSN: 10165169 PUBMED, SCOPUS
Prof. Dr. SÜLEYMAN BALDANE →
Atrial Fibrillation due to Right Atrial Compression in a Patient with Pectus Excavatum
2012 ISSN: 10165169 EBSCO
Doç. Dr. MUHAMMED ULVİ YALÇIN →
Pulmonary vein anatomy and its variations in a Turkish atrial fibrillation cohort undergoing cryoballoon-based catheter ablation
2017 ISSN: 10165169 ESCI (Emerging Sources Citation Index)
Doç. Dr. MUHAMMED ULVİ YALÇIN →
The prevalence of coronary artery anomalies in patients undergoing multidetector computed tomography for the evaluation of coronary artery disease
2010 ISSN: 1016-5169 TR DİZİN
Doç. Dr. KADRİ MURAT GÜRSES →
Porcelain thoracic aorta in a patient with rheumatoid arthritis
2013 ISSN: 10165169 TR DİZİN
Doç. Dr. KADRİ MURAT GÜRSES →
Emergency revascularization procedures in patients with acute ST-elevation myocardial infarction due to acute total occlusion of unprotected left main coronary artery: a report of five cases.
2009 ISSN: 1016-5169 Art Index (Art Research Database, EBSCO)
Prof. Dr. NAZİF AYGÜL →
Cardiac metastasis of renal cell carcinoma without inferior vena cava involvement: case report
2013 ISSN: 10165169 TR DİZİN
Doç. Dr. ABİDİN KILINÇER →
A rare cause of exertional dyspnea and cyanosis in an adolescent patient: Pulmonary arteriovenous malformation and successful Treatment
2019 ISSN: 10165169 EBSCO
Prof. Dr. AHMET SERT →
Serum galectin-3 level predicts early recurrence following successful direct current cardioversion in persistent atrial fibrillation patients.
2019 ISSN: 10165169 ESCI (Emerging Sources Citation Index)
Doç. Dr. MUHAMMED ULVİ YALÇIN →
A rare cause of exertional dyspnea and cyanosis in an adolescent patient: Pulmonary arteriovenous malformation and successful Treatment
2019 ISSN: 1016-5169 TR DİZİN
Prof. Dr. MUSTAFA KOPLAY →
A rare coexistence: giant floating aortic thrombus and pulmonary embolism in a patient with pancreatic cancer
2011 ISSN: 1016-5169 TR DİZİN
Prof. Dr. YASEMİN COŞKUN YAVUZ →
Association between Reverse Electrical Remodeling and Cardiac Fibrosis Markers in Patients with Cardiac Resynchronization Therapy
2017 ISSN: 1016-5169 ESCI (Emerging Sources Citation Index)
Doç. Dr. MUHAMMED ULVİ YALÇIN →
An epidemiological study to evaluate the use of vitamin K antagonists and new oral anticoagulants among nonvalvular atrial fibrillation patients in Turkey- AFTER-2 Study Design
2015 ISSN: 1016-5169 ESCI (EMERGING SOURCES CITATION INDEX
Prof. Dr. ABDULLAH TUNÇEZ →
Hypertrophic cardiomyopathy with Jeune syndrome: The first reported case
2016 ISSN: 1016-5169 TR DİZİN
Dr. Öğr. Üyesi SAİME SÜNDÜS UYGUN →
Successful therapy of giant right atrial aneurysm accompanying tricuspid valve dysplasia in a child
2021 ISSN: 1016-5169 ESCİ
Prof. Dr. MEHMET ALKILIÇ HORASANI ÖÇ →
Prediction of the development of pulmonary arterial hypertension with Tei index in children
2019 ISSN: 1016-5169 Google scholar
Prof. Dr. ALAADDİN YORULMAZ →
Effect of disease severity on upper extremity muscle strength, exercise capacity, and activities of daily living in individuals with pulmonary arterial hypertension
2017 ISSN: 1016-5169 TR DİZİN
Doç. Dr. İSMAİL ÖZSOY →
Successful therapy of giant right atrial aneurysm accompanying tricuspid valve dysplasia in a child
2021 ISSN: 1016-5169 ESCİ
Prof. Dr. BAHAR ÖÇ →
Distal transradial versus conventional transradial access in acute coronary syndrome
2021 ISSN: 1016-5169 TR DİZİN
Doç. Dr. KENAN ERDEM →
Makale Bilgileri
ISSN10165169
Yayın TarihiMart 2026
Cilt / Sayfa54 · 141-146
Scopus ID2-s2.0-105030755813
Erişim🔓 Açık Erişim
Özet
Objective: Microvascular angina (MVA), a phenotype of ischemia with non obstructive coronary arteries, produces chest pain despite normal epicardial vessels. Central sensitization (CS) may amplify symptoms, but its magnitude in confirmed MVA is unclear.Method: We conducted a single center cross sectional study. Adults with MVA undergoing coronary angiography and age- and sex matched healthy volunteers completed the Central Sensitization Inventory (CSI), Hospital Anxiety and Depression Scale (HADS), and chest pain questionnaires. MVA required documented ischemia with ≤ 50% epicardial stenosis. The primary outcome was the difference in mean CSI score; secondary outcomes were the proportion with CSI ≥ 40 and correlations between CSI, angina measures, and HADS subscores. Results: We enrolled 200 participants; 138 (69%) were male; and the mean age was 61 ± 11 years. Mean CSI-Part A was higher in MVA versus controls (43 ± 15 vs. 19 ± 11; P < 0.001), and clinically significant CS was more prevalent (62% vs. 10%). Within MVA, CSI correlated with chest pain intensity (r = 0.58), weekly episode frequency (r = 0.46), HADS-Anxiety (r = 0.51), and HADS-Depression (r = 0.44) (all P < 0.001). In adjusted models, each 10-point increase in CSI was associated with a 0.47 standard deviation rise in pain score (β = 0.47, 95% confidence interval 0.29–0.64; P < 0.001); the model explained 39% of pain-score variance (R<sup>2</sup> = 0.39). Conclusion: Central sensitization is highly prevalent and strongly linked to angina burden in MVA, supporting a heart brain contribution to symptom generation. Interventions that reduce central pain amplification may provide meaningful benefit beyond standard anti ischemic therapy.
Yazarlar (10)
1
Hüseyin Tezcan
2
Kadri Murat Gurses
3
Muhammed Ulvi Yalçın
4
Yasin Özen
5
Bulent Behlul Altunkeser
6
Nazif Aygül
7
Kenan Demir
8
Abdullah Tunçez
9
Esra Şen Bülbül
ORCID: 0009-0004-6370-9655
10
Ezgi Akyildiz Tezcan
ORCID: 0000-0002-4988-1270
Anahtar Kelimeler
Central sensitization
chest pain amplification
coronary microvascular dysfunction
ischemia with non-obstructive coronary arteries
microvascular angina
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turk Kardiyoloji Dernegi Arsivi
Q4
OA
SJR Skoru0,220
H-Index31
YayıncıTurkish Society of Cardiology
ÜlkeTurkey
Cardiology and Cardiovascular Medicine (Q4)