Scopus
🔓 Açık Erişim
Cord blood cardiac markers and tissue doppler echocardiography findings in infants of diabetic mothers
Italian Journal of Pediatrics · Aralık 2026
Makale Bilgileri
DergiItalian Journal of Pediatrics
Yayın TarihiAralık 2026
Cilt / Sayfa52
Scopus ID2-s2.0-105030304833
Erişim🔓 Açık Erişim
Özet
Background: Maternal diabetes mellitus (DM) significantly affects fetal cardiac and placental structure and function. This study aimed to assess structural and functional cardiac changes in infants of diabetic mothers (IDMs) using echocardiographic data and cord blood cardiac biomarkers. Methods: M-mode and pulsed-wave tissue Doppler imaging (PW-TDI) echocardiography along with cord blood cardiac markers were evaluated in 40 IDMs and 40 healthy term newborns. Cardiac biomarkers included troponin T (Trop-T), N-terminal pro-brain natriuretic peptide (NT-proBNP), and ischemia-modified albumin (IMA). Results: Among the diabetic mothers, 87.5% had gestational diabetes mellitus (GDM) and 12.5% had type 1 diabetes mellitus (T1DM). Interventricular septum (IVS) thickness was significantly greater in the IDM group. Of the IDMs, 32.5% had asymmetric septal hypertrophy. Mid-septal tissue Doppler Imaging (TDI) parameters showed significantly altered velocities and time intervals. NT-proBNP and IMA levels were significantly elevated in the IDMs group, while Trop-T was not statistically different. No correlation was found between TDI parameters and biomarker levels. Conclusion: Cardiac dysfunction and elevated cord blood biomarkers in IDMs reflect subclinical stress. These findings support the utility of TDI and biochemical markers for early cardiac assessment in IDMs. Larger studies are needed to validate the use of these markers for routine screening and to better understand their pathophysiological significance.
Yazarlar (11)
1
Sema Nur Taşkın
ORCID: 0000-0003-3400-1514
2
Vehbi Doğan
3
Zeynep Kasap Acungil
4
Rüveyda Gümüşer Cinni
5
Serap Bilge
ORCID: 0000-0002-4265-3363
6
Şeyma Ünüvar Gök
7
Leyla Aydoğan
8
İsmail Benli
9
Arzu Er Kara
10
Deniz Anuk İnce
11
Resul Yilmaz
Anahtar Kelimeler
Cardiac biomarkers
Infant of diabetic mothers (IDMs)
Ischemia-modified albumin (IMA)
N-terminal pro-brain natriuretic peptide (NT-proBNP)
Tissue doppler imaging (TDI)
Troponin T (Trop-T)
Kurumlar
Tokat Gaziosmanpaşa Üniversitesi
Tokat Turkey
Tokat State Hospital
Tokat Turkey