Scopus
The impact of injection site on the pharmacokinetics of danofloxacin in Pekin ducks (Anas platyrhynchos domestica)
Research in Veterinary Science · Mayıs 2026
Makale Bilgileri
DergiResearch in Veterinary Science
Yayın TarihiMayıs 2026
Cilt / Sayfa203
Scopus ID2-s2.0-105030965544
Özet
The purpose of this study was to investigate the influence of injection site on danofloxacin pharmacokinetics in Pekin ducks. Thirty-two male Peking ducks were divided into 4 equal groups as intravenous (IV), pectoral muscles (IMP), thigh muscles (IMT) and subcutaneous (SC). Danofloxacin was administered to all groups at a dose of 10 mg/kg. Plasma concentrations of danofloxacin were quantified by HPLC-UV. The volume of distribution at steady state and total clearance values of danofloxacin after IV injections in ducks were 4.43 L/kg and 0.42 L/h/kg, respectively. The terminal elimination half-life (t<inf>1/2ʎz</inf>), area under the concentration-versus time curve (AUC)<inf>0-last</inf>, and peak plasma concentration (C<inf>max</inf>) were similar after SC and IMP injections of danofloxacin. However, t<inf>1/2ʎz</inf> was shorter and AUC<inf>0-last</inf> and C<inf>max</inf> were lower in the IMT group compared to the IMP group. The bioavailability was lower in the IMT group than in the IMP and SC groups. Danofloxacin exhibited similar pharmacokinetic profiles after SC and IMP injection into Pekin ducks. In the IMT group, pharmacokinetics altered significantly, resulting in reduced body exposure and residence time of danofloxacin. Optimizing the injection site to subcutaneous or pectoral muscle routes may improve danofloxacin's therapeutic efficacy in Pekin ducks, while caution should be applied with thigh muscle injections due to reduced bioavailability and systemic exposure.
Yazarlar (11)
1
Kamil Üney
ORCID: 0000-0002-8674-4873
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
D. Durna Corum
4
Devran Coskun
ORCID: 0000-0003-1151-1861
5
Pedro Marin
ORCID: 0000-0003-4849-4452
6
M. Giorgi
ORCID: 0000-0003-3657-4703
7
Amnart Poapolathep
8
Saranya Poapolathep
9
Tugce Karaahmetli
10
E. Yazar
11
M. Elmas
Anahtar Kelimeler
Danofloxacin
Injection site
Pekin duck
Pharmacokinetics
Renal portal system
Kurumlar
Kasetsart University
Bangkok Thailand
Selçuk Üniversitesi
Selçuklu Turkey
Siirt Üniversitesi
Siirt Turkey
Universidad de Murcia
Murcia Spain
Università di Pisa
Pisa Italy
University of Hatay Mustafa Kemal
Hatay Turkey