Scopus
YÖKSİS DOI Eşleşti
SJR Q1
The Effect of Zinc and Melatonin Administration on Lipid Peroxidation, IL-6 Levels, and Element Metabolism in DMBA-Induced Breast Cancer in Rats
Biological Trace Element Research · Mart 2021
YÖKSİS Kayıtları
The Effect of Zinc and Melatonin Administration on Lipid Peroxidation, IL-6 Levels, and Element Metabolism in DMBA-Induced Breast Cancer in Rats
Biological Trace Element Research · 2021 SCI-Expanded
Prof. Dr. RASİM MOĞULKOÇ →
The Effect of Zinc and Melatonin Administration on Lipid Peroxidation, IL-6 Levels and Element Metabolism in DMBA-Induced Breast Cancer in Rats.
Biological Trace Element Research · 2021 SCI-Expanded
Prof. Dr. ABDULKERİM KASIM BALTACI →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Investigation of the Relationship Between Serum Trace Elements and MSFC Levels in Multiple Sclerosis: A Cross-sectional Case-Control Study
2025 ISSN: 0163-4984 SCI
Dr. Öğr. Üyesi CİHAT ÖZGÜNCÜ →
Effects of Zinc Deficiency and Supplementation on Malondialdehyde and Glutathione Levels in Blood and Tissues of Rats Performing Swimming Exercise
2003 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Effect of Selenium Supplementation on Lipid Peroxidation Antioxidant Enzymes and Lactate Levels in Rats Immediately After Acute Swimming Exercise
2011 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Effects of dietary cadmium and boron supplementation on performance eggshell quality and mineral concentrations of bone in laying hens
2015 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. OSMAN OLGUN →
Serum and Cerebrospinal Fluid Magnesium Levels Glasgow Coma Scores and In Hospital Mortality in Patients with Acute Stroke
2009 ISSN: 0163-4984 SCI
Prof. Dr. HASAN KARA →
Magnesium Sulfate in Emergency Department Patients with Hypertension
2009 ISSN: 0163-4984 SCI
Prof. Dr. HASAN KARA →
Levels of Selenium Zinc Copper and Cardiac Troponin I in Serum of Patients with Acute Coronary Syndrome
2013 ISSN: 0163-4984 SSCI
Prof. Dr. HASAN KARA →
Elements in Sera of Elite Taekwondo Athletes Effects of Vitamin E Supplementation
2011 ISSN: 0163-4984 SCI 3 atıf
Prof. Dr. EKREM BOYALI →
The Effect of Vitamin A Supplementation on Various Elements in Elite Taekwondo Players
2011 ISSN: 0163-4984 SCI 2 atıf
Prof. Dr. EKREM BOYALI →
Effects of Exercise and Zinc Supplementation on Cytokine Release in Young Wrestlers
2011 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. MEHMET KILIÇ →
Effect of Intraperitoneal Selenium Administration on Liver Glycogen Levels in Rats Subjected to Acute Forced Swimming
2011 ISSN: 0163-4984 SSCI
Prof. Dr. MEHMET KILIÇ →
Effects of Acute Swimming Exercise on Some Elements in Rats
2009 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. MEHMET KILIÇ →
Effect of Zinc Supplementation on Antioxidant Activity in Young Wrestlers
2010 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. MEHMET KILIÇ →
Effects of Chronic Fluorosis on Electrocardiogram in Sheep
2003 ISSN: 0163-4984 SCI-Expanded 24 atıf
Prof. Dr. NURCAN DÖNMEZ →
Effect of Zinc Supplementation on Antioxidant Activity in Young Wrestlers
2010 ISSN: 0163-4984 SCI-Expanded 10 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Testosterone Levels in Athletes at Rest and Exhaustion Effects of Calcium Supplementation
2009 ISSN: 0163-4984 SCI-Expanded 3 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Effects of Magnesium Supplementation on Testosterone Levels of Athletes and Sedentary Subjects at Rest and after Exhaustion
2011 ISSN: 0163-4984 SCI-Expanded 6 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Effects of zinc deficiency and supplementation on malondialdehyde and glutathione levels in blood and tissue of rats performing swimming exercise
2003 ISSN: 0163-4984 SCI-Expanded 18 atıf
Prof. Dr. ABDULKERİM KASIM BALTACI →
Effects of exercise and zinc supplementation on cytokine release in young wrestlers
2011 ISSN: 0163-4984 SSCI 4 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Effects of zinc supplementation on the element distribution in kidney tissue of diabetic rats subjected to acute swimming
2012 ISSN: 0163-4984 SSCI 5 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Makale Bilgileri
ISSN01634984
Yayın TarihiMart 2021
Cilt / Sayfa199 · 1044-1051
Scopus ID2-s2.0-85086776209
Özet
The purpose of this study was to investigate the effects of zinc and melatonin administration on interleukin-6, lipid peroxidation parameters, and element metabolism in DMBA-induced breast cancer in female rats. A total of 42 recently weaned Wistar rats were divided into 5 groups as follows: control (group 1), DMBA control (group 2), DMBA + zinc (group 3), DMBA + melatonin (group 4), and DMBA + melatonin and zinc (group 5). Malondialdehyde (MDA) and glutathione (GSH) levels in breast tissue and blood samples were determined via spectrophotometric methods. In addition, iron, magnesium, zinc, and copper levels in serum samples were determined by atomic emission, and plasma interleukin-6 levels were determined by ELISA method. The highest tissue and plasma MDA and the lowest tissue and erythrocyte GSH levels found in the study were in group 2; the highest tissue and erythrocyte GSH levels and the lowest tissue and plasma MDA levels are in group 5 (P < 0.05). Iron, magnesium, and zinc levels of groups 3, 4, and 5 were higher than the DMBA group without administration (group 2), but the copper values were significantly lower (P < 0.05). The highest IL-6 levels were determined in group 2 while IL-6 levels in the DMBA group (G5) treated with combined melatonin and zinc were lower than all other breast cancer groups (P < 0.05). According to the findings obtained in this presented study, combined zinc and melatonin therapy can contribute to the prevention of tumor growth by improving the disruption in element metabolism and suppressing IL-6 levels and reducing tissue damage that causes the cancer.
Yazarlar (5)
1
Elif Gulbahce-Mutlu
2
Saltuk Bugra Baltaci
3
Esma Menevşe
4
Rasim Mogulkoc
5
Abdulkerim Kasim Baltaci
Anahtar Kelimeler
Breast cancer
DMBA
IL-6
Lipid peroxidation
Rat
Trace element
Kurumlar
Karatay Üniversitesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Biological Trace Element Research
Q1
OA
SJR Skoru0,890
H-Index119
YayıncıSpringer
ÜlkeUnited States
Inorganic Chemistry (Q1)
Biochemistry (Q2)
Biochemistry (medical) (Q2)
Clinical Biochemistry (Q2)
Endocrinology, Diabetes and Metabolism (Q2)
Medicine (miscellaneous) (Q2)
Metrikler
27
Atıf
5
Yazar
6
Anahtar Kelime