Scopus
YÖKSİS Eşleşti
Design and characterization of pH stimuli-responsive nanofiber drug delivery system: The promising targeted carriers for tumor therapy
Journal of Applied Polymer Science · Mart 2021
YÖKSİS Kayıtları
Design and characterization of pH stimuli-responsive nanofiber drug delivery system: The promising targeted carriers for tumor therapy
JOURNAL OF APPLIED POLYMER SCIENCE · 2020 SCI-Expanded
ÖĞRETİM GÖREVLİSİ FATİH ÖZCAN →
Makale Bilgileri
DergiJournal of Applied Polymer Science
Yayın TarihiMart 2021
Cilt / Sayfa138
Scopus ID2-s2.0-85092174935
Özet
New carrier platforms have been designed for an electrospun pyridinium calixarene nanofiber for controlled drug delivery. First, 5,11,17,23-tetra-tert-butyl-25,27-bis(3-aminomethyl-pyridineamido)-26,28-dihydroxycalix[4]arene (3-AMP) scaffold was produced by electrospinning. AMP scaffold was modified by human serum albumin (HSA), folic acid (FA), and glutathione (GSH). Doxorubicin (DOX) was loaded to surfaces of the AMP, AMP-HSA, AMP-HSA-FA, and AMP-HSA-GSH nanofibers by using DOX solution in different buffers with, 2.2, 4.0, 6.0, and 7.4 pH. The release studies DOX from four different nanofibers was also done in a various amount microenviroments by changing pH values. The loading and release amount of DOX was estimated from the calibration curve drawn at 480 and 560 nm of excitation and emission wavelengths by using a fluorescence spectrophotometer. The loading studies were confirmed by Fourier transforms infrared, atomic force microscopy, transmission electron microscopy, scanning electron microscope, and energy-dispersive X-ray (EDX) analysis.
Yazarlar (2)
1
Fatih Ozcan
2
Esra Maltas Cagil
Anahtar Kelimeler
biomedical applications
drug delivery systems
electrospinning
stimuli-sensitive polymers
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
16
Atıf
2
Yazar
4
Anahtar Kelime