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Production and characterization of a new targeted pH-responsive sporopollenin system for controlled drug release

Macromolecular Research · Ocak 2024

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YÖKSİS Kayıtları
Production and characterization of a new targeted pH-responsive sporopollenin system for controlled drug release
MACROMOLECULAR RESEARCH · 2024 SCI-Expanded
Arş. Gör. KÜBRA YILMAZ →
Production and characterization of a new targeted pH-responsive sporopollenin system for controlled drug release
Macromolecular Research · 2024 SCI-Expanded
Prof. Dr. ESRA MALTAŞ ÇAĞIL →
Production and characterization of a new targeted pH-responsive sporopollenin system for controlled drug release
Macromolecular Research · 2024 SCI-Expanded
Prof. Dr. İLKAY HİLAL GÜBBÜK →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 8 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Synthesis and Application of Novel Magnetite Nanoparticle Based Azacrown Ether for Protein Recognition
2013 ISSN: 1598-5032 SCI 4 atıf
Prof. Dr. MUSTAFA ÖZMEN →
Synthesis and properties of calix 4 arene polymers containing amide groups Exploration of their extraction properties towards dichromate and nitrite anions
2013 ISSN: 1598-5032 SCI-Expanded
Prof. Dr. EZGİ AKCEYLAN →
Synthesis and application of novel magnetite nanoparticle based azacrown ether for protein recognition
2013 ISSN: 1598-5032 SCI-Expanded 3 atıf
Prof. Dr. ESRA MALTAŞ ÇAĞIL →
Preparation of hexagonal boron nitride polymer systems with one-step sol–gel synthesis for pH-controlled drug delivery
2024 ISSN: 1598-5032 SCI-Expanded Q2
Öğr. Gör. FATİH ÖZCAN →
Production and characterization of a new targeted pH-responsive sporopollenin system for controlled drug release
2024 ISSN: 1598-5032 SCI-Expanded Q2
Arş. Gör. KÜBRA YILMAZ →
Production and characterization of a new targeted pH-responsive sporopollenin system for controlled drug release
2024 ISSN: 1598-5032 SCI-Expanded Q2
Prof. Dr. ESRA MALTAŞ ÇAĞIL →
Preparation of hexagonal boron nitride polymer systems with one-step sol–gel synthesis for pH-controlled drug delivery
2024 ISSN: 1598-5032 SCI-Expanded Q2
Prof. Dr. ESRA MALTAŞ ÇAĞIL →
Production and characterization of a new targeted pH-responsive sporopollenin system for controlled drug release
2024 ISSN: 1598-5032 SCI-Expanded Q2
Prof. Dr. İLKAY HİLAL GÜBBÜK →

Makale Bilgileri

Dergi Macromolecular Research
ISSN15985032
Yayın TarihiOcak 2024
Cilt / Sayfa32 · 45-57
DOI10.1007/s13233-023-00202-0
Scopus ID2-s2.0-85173936866
Özet A new pH stimuli drug carrier platform was fabricated based on amine modified sporopollenin for targeted and controlled drug delivery. For this purpose, human serum albumin (HSA) was immobilized on 3-aminopropyltrimethoxysilane functionalized sporopollenin (Sp-APTS). Then, irinotecan (IR) was loaded to the albumin modified sporopollenin at various pH levels (2.2, 4.0, 6.0, 7.4, and 9.0). The release studies of irinotecan from drug loaded sporopollenin systems were carried out by using buffers at various pH levels such as 2.2, 4.0, 6,0, 7.4, and 9.0. The loading and release amount of IR were determined by using fluorescence spectroscopy. the results showed that the maximum loading pH was pH 4.0 with 23.44 µg. we evaluate the results in terms of the controlled release, the systems are more controllable towards basic region after pH 4.0 depends on time and pH level. Characterization of the systems was run by using thermal gravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) analysis. One of the biodegradable biopolymers, polysaccharide based controlled drug delivery system makes the pharmaceutical formulation more bioavailable in cancer therapy. Graphical abstract: This study examines the synthesis of the APTS modified sporopollenin (Sp-APTS) for a controlled drug release system. Immobilization of albumin and drug loading to the Sp-APTS-HSA were carried out for development of pH-responsive release system.[Figure not available: see fulltext.]

Yazarlar (3)

1
Kubra Yilmaz
2
Ilkay Hilal Gubbuk
3
Esra Maltas Cagil

Anahtar Kelimeler

Controlled drug release Pharmaceuticals Sporopollenin Thermodynamic

Kurumlar

Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Macromolecular Research
Q2 OA
SJR Skoru0,585
H-Index60
YayıncıPolymer Society of Korea
ÜlkeSouth Korea
Chemical Engineering (miscellaneous) (Q2)
Materials Chemistry (Q2)
Organic Chemistry (Q2)
Polymers and Plastics (Q2)
Dergi sayfasına git

Metrikler

4
Atıf
3
Yazar
4
Anahtar Kelime

Sistemimizdeki Yazarlar

EM
ESRA MALTAŞ ÇAĞIL
Prof. Dr.

Hızlı Erişim

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