Scopus
YÖKSİS Eşleşti
Curcumin and quercetin modulate oxidative stress and inflammation of healthy lung cells treated with sol-gel graphene oxide nanoparticles
Biochemical and Biophysical Research Communications · Eylül 2025
YÖKSİS Kayıtları
Curcumin and quercetin modulate oxidative stress and inflammation of healthy lung cells treated with sol-gel graphene oxide nanoparticles
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS · 2025 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ KÜBRA YILMAZ →
Curcumin and quercetin modulate oxidative stress and inflammation of healthy lung cells treated with sol-gel graphene oxide nanoparticles
Biochemical and Biophysical Research Communications · 2025 SCI-Expanded
PROFESÖR ESMA MENEVŞE →
Makale Bilgileri
DergiBiochemical and Biophysical Research Communications
Yayın TarihiEylül 2025
Cilt / Sayfa782
Scopus ID2-s2.0-105014968136
Özet
This study investigates the cytotoxic and biochemical effects of PEGylated graphene oxide sol-gel (SJ-go) nanoparticles, curcumin, and quercetin on BEAS-2B human bronchial epithelial. In this work, a new graphene oxide nanocomposite (SJ-go) was produced using the sol-gel method through a one-step reaction. These hybrid sol-gel systems include graphite, triethyl orthosilicate (TEOS), and polyethylene glycol (PEG) having a molecular weight of 8000 g/mol. IC<inf>50</inf> value for SJ-go was found to be 318.86 μg/mL. While IC<inf>50</inf> value of curcumin was 28.99 μM, it was 169.40 μM. SJ-go at 150 μg/mL decreased the Glutathione Peroxidase (GSH-Px) activity from 32.14 ± 1.51 U/mg to 4.18 ± 0.02 U/mg protein when compared with positive control without nanoparticles. Data showed the SJ-go at the highest concentration was more effective on GSH-Px in terms of cytotoxic when compared with SJ-go, itself without treatment with any substances for antioxidant mechanism. When considering natural substances, the curcumin was also more effective than the quercetin on SJ-go treated BEAS-2B at all concentrations of the sol-gel graphene oxide in terms of GSH-Px levels below and above IC<inf>50</inf> value. Interleukin-6 (IL-6) analysis indicated that the curcumin has more anti-inflammatory effect than quercetin at all nanoparticles’ concentrations.
Yazarlar (5)
1
Esra Maltas Cagil
ORCID: 0000-0001-7574-6016
2
Fatih Ozcan
3
Emine N. Korucu
4
Kubra Yilmaz Kuvvet
5
Esma Menevşe
Anahtar Kelimeler
Graphene oxide
Interleukin-6
Quercetin
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey