Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Identification and antifungal susceptibility of Candida species isolated from bloodstream infections in Konya, Turkey
Annals of Clinical Microbiology and Antimicrobials · Mayıs 2016
YÖKSİS Kayıtları
Identification and antifungal susceptibility of Candida species isolated from bloodstream infections in Konya Turkey
Annals of Clinical Microbiology and Antimicrobials · 2016 SCI-Expanded
PROFESÖR HATİCE TÜRK DAĞI →
Identification and antifungal susceptibility of Candida species isolated from bloodstream infections in Konya Turkey
Annals of Clinical Microbiology and Antimicrobials · 2016 SCI-Expanded
PROFESÖR UĞUR ARSLAN →
Makale Bilgileri
DergiAnnals of Clinical Microbiology and Antimicrobials
Yayın TarihiMayıs 2016
Cilt / Sayfa15
Scopus ID2-s2.0-84971510714
Erişim🔓 Açık Erişim
Özet
Background: In this study, our aim was to identify Candida species isolated from bloodstream infections and to determine their susceptibilities to various antifungal agents to demonstrate the local resistance profiles and to guide empirical treatment for clinicians. Methods: Two hundred Candida isolates (95Candida albicans, 105 non-albicans Candida strains) were included in the study. Candida species were identified by conventional, biochemical and molecular methods. Antifungal susceptibility tests for amphotericin B, fluconazole, voriconazole, posaconazole, caspofungin and anidulafungin were performed with broth microdilution method according to the Clinical and Laboratory Standards Institute M27-A3 document. Results: Of the 200 Candida strains, the most prevalent species were C. albicans (47.5%), Candida glabrata (18.0%) and Candida parapsilosis complex (14.0%). All Candida species except for three (1.5%) Candida kefyr strains were susceptible to amphotericin B. Only one (2.8%) C. glabrata was resistant to fluconazole (MIC ≥ 64 μg/ml), and the others (97.2%) exhibited dose-dependent susceptibility. All species, but C. glabrata strains, were susceptible to fluconazole. Resistance to voriconazole, posaconazole, caspofungin and anidulafungin was not detected in any strain. Conclusion:Candida albicans were susceptible to all antifungal drugs. Three C. kefyr strains were resistant to amphotericin B. Only one C. glabrata was resistant to fluconazole. All the strains were susceptible to voriconazole, posaconazole, caspofungin and anidulafungin. In vitro antifungal susceptibility tests should be performed to select of appropriate and effective antifungal therapy, and monitor the development of resistance.
Yazarlar (4)
1
Hatice Türk Dağı
2
Duygu Findik
3
Cigdem Senkeles
4
Ugur Arslan
Anahtar Kelimeler
Anti-fungal susceptibility
Candida
Microdilution method
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
45
Atıf
4
Yazar
3
Anahtar Kelime