Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota
Nature Communications · Aralık 2017
YÖKSİS Kayıtları
Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota
Nature Communications · 2017 SCI
PROFESÖR HATİCE TÜRK DAĞI →
Makale Bilgileri
DergiNature Communications
Yayın TarihiAralık 2017
Cilt / Sayfa8
Scopus ID2-s2.0-85033405401
Erişim🔓 Açık Erişim
Özet
Campylobacter fetus is a venereal pathogen of cattle and sheep, and an opportunistic human pathogen. It is often assumed that C. fetus infection occurs in humans as a zoonosis through food chain transmission. Here we show that mammalian C. fetus consists of distinct evolutionary lineages, primarily associated with either human or bovine hosts. We use whole-genome phylogenetics on 182 strains from 17 countries to provide evidence that C. fetus may have originated in humans around 10,500 years ago and may have "jumped" into cattle during the livestock domestication period. We detect C. fetus genomes in 8% of healthy human fecal metagenomes, where the human-associated lineages are the dominant type (78%). Thus, our work suggests that C. fetus is an unappreciated human intestinal pathobiont likely spread by human to human transmission. This genome-based evolutionary framework will facilitate C. fetus epidemiology research and the development of improved molecular diagnostics and prevention schemes for this neglected pathogen.
Yazarlar (28)
1
Gregorio Iraola
2
Samuel C. Forster
3
Nitin Kumar
4
Philippe Lehours
5
Sadjia Bekal
6
Francisco J. García-Peña
7
Fernando Paolicchi
8
Claudia Morsella
9
Helmut Hotzel
10
Po Ren Hsueh
11
Ana Vidal
12
Simon Lévesque
13
Wataru Yamazaki
14
Claudia Balzan
15
Agueda Vargas
16
Alessandra Piccirillo
17
Bonnie Chaban
18
Janet E. Hill
19
Laura Betancor
20
Luis Collado
21
Isabelle Truyers
22
Anne C. Midwinter
23
Hatice Türk Dağı
24
Francis Mégraud
25
Lucía Calleros
26
Ruben Pérez
27
Hugo Naya
28
Trevor D. Lawley
Kurumlar
Animal and Plant Health Agency
Addlestone United Kingdom
Friedrich-Loeffler-Institute
Greifswald Germany
Hudson Institute of Medical Research
Clayton Australia
Institut National de Sante Publique Du Québec
Quebec Canada
Instituto Nacional de Tecnología Agropecuaria Buenos Aires
Buenos Aires Argentina
Institut Pasteur de Montevideo
Montevideo Uruguay
Laboratorio Central de Veterinaria de Algete (MAGRAMA)
Madrid Spain
Massey University
Palmerston North New Zealand
Monash University
Melbourne Australia
National Taiwan University Hospital
Taipei Taiwan
Selçuk Üniversitesi
Selçuklu Turkey
The Royal (Dick) School of Veterinary Studies
Roslin United Kingdom
Universidad Austral de Chile
Valdivia Chile
Universidad de la Republica
Montevideo Uruguay
Universidad de la Republica Instituto de Higiene
Montevideo Uruguay
Universidade Federal de Santa Maria
Santa Maria Brazil
Università degli Studi di Padova
Padua Italy
Université de Bordeaux
Bordeaux France
University of Miyazaki
Miyazaki Japan
University of Montreal
Montreal Canada
University of Saskatchewan
Saskatoon Canada
University of the Sunshine Coast
Sippy Downs Australia
Wellcome Sanger Institute
Hinxton United Kingdom
Metrikler
48
Atıf
28
Yazar