Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Diagnostic Value of Serum Clara Cell Secretory Protein Level in an Experimental Blunt Chest Trauma Model
Genel Tip Dergisi · Ekim 2024
YÖKSİS Kayıtları
Diagnostic value of serum Clara cell secretory protein level in an experimental blunt chest trauma model
Genel Tıp Dergisi · 2024 EBSCO, DOAJ
DOKTOR ÖĞRETİM ÜYESİ NEJAT ÜNLÜKAL →
Diagnostic Value of Serum Clara Cell Secretory Protein Level in an Experimental Blunt Chest Trauma Model
Genel Tıp Dergisi · 2024 TR DİZİN
PROFESÖR AHMET AK →
Diagnostic value of serum Clara cell secretory protein level in an experimental blunt chest trauma model
Genel Tıp Dergisi · 2024 EBSCO, DOAJ
DOKTOR ÖĞRETİM ÜYESİ YEŞİM ŞERİFE BAYRAKTAR →
Diagnostic value of serum Clara cell secretory protein level in an experimental blunt chest trauma model
Genel Tıp Dergisi · 2024 EBSCO, DOAJ
DOKTOR ÖĞRETİM ÜYESİ ATİLLA CAN →
Diagnostic Value of Serum Clara Cell Secretory Protein Level in an Experimental Blunt Chest Trauma Model
Genel Tıp Dergisi · 2024 TR DİZİN
DOKTOR ÖĞRETİM ÜYESİ ATİLLA CAN →
Diagnostic Value of Serum Clara Cell Secretory Protein Level in an Experimental Blunt Chest Trauma Model
Genel Tıp Dergisi · 2024 TR DİZİN
PROFESÖR HASAN KARA →
Diagnostic value of serum Clara cell secretory protein level in an experimental blunt chest trauma model
Genel Tıp Dergisi · 2024 EBSCO, DOAJ
PROFESÖR BAHADIR ÖZTÜRK →
Diagnostic Value of Serum Clara Cell Secretory Protein Level in an Experimental Blunt Chest Trauma Model
Genel Tıp Dergisi · 2024 TR DİZİN
PROFESÖR AYŞEGÜL BAYIR →
Makale Bilgileri
DergiGenel Tip Dergisi
Yayın TarihiEkim 2024
Cilt / Sayfa34 · 660-665
Scopus ID2-s2.0-105009419827
Erişim🔓 Açık Erişim
Özet
Objective: Blunt chest trauma is a significant clinical problem leading to injury of the lungs that may be fatal. Experimental blunt chest trauma is well established in animal models. This study aimed to investigate whether Clara cell secretory protein (CC16) can be a biomarker in an experimentally created blunt chest trauma model. Material and Methods: A total of 30 rabbits were used in our study. A modified bilateral blunt thoracic trauma model was used to produce different levels of lung contusion. We divided the rabbits into four groups according to the energy level at which blunt thoracic trauma was applied. Blood samples were taken from the control and trauma groups to evaluate CC16 levels at 0, 12, and 24 hours. Results: The CC16 levels measured at the start of the experiment were significantly lower in the control and low-energy groups compared to the medium-and high-energy groups (p =.002). While there was a significant difference in CC16 levels measured at the 12th hour (p =.004), no significant difference was found among the groups at the 24th hour. Upon analyzing the change in CC16 levels over time within the groups, we observed that CC16 levels decreased from 0–12 hours and subsequently increased after the 12th hour. Histopathologically, we observed that the level of contusion increased in proportion to the severity of trauma across the different groups. Conclusion: With the designed platform, we created a reproducible experimental model of pulmonary contusion from blunt thoracic trauma in rabbits. Increased levels of CC16 following a lung contusion could serve as a foundation for clinical decision-making. Thus, CC16 has the potential to serve as a rapid and simple biochemical indicator for acute traumatic lung injury.
Yazarlar (10)
1
Hasan Kara
2
Ayşegül Bayır
ORCID: 0000-0002-5680-031X
3
Ahmet Ak
4
Yesim Serife Bayraktar
ORCID: 0000-0001-5156-7064
5
Atilla Can
ORCID: 0000-0002-9603-2861
6
Bahadır Öztürk
7
Nejat Ünlükal
ORCID: 0000-0002-8107-4882
8
Fatih Akbuğa
ORCID: 0000-0003-0257-5919
9
Abdullah Akkuş
ORCID: 0000-0001-9452-3889
10
Muhammed Eseroğlu
ORCID: 0000-0003-2693-5878
Anahtar Kelimeler
Biomarker
Blunt chest trauma
CC16
Experimental
Kurumlar
Bünyan State Hospital
Kayseri Turkey
Cihanbeyli State Hospital
Konya Türkiye
Selçuk Tip Fakültesi
Konya Turkey
Suhut State Hospital
Afyon Turkey