Scopus
🔓 Açık Erişim
Plasma and Muscle Pharmacokinetics of Ceftriaxone in Nile Tilapia (Oreochromis niloticus) After Different Administration Routes
Antibiotics · Aralık 2025
Makale Bilgileri
DergiAntibiotics
Yayın TarihiAralık 2025
Cilt / Sayfa14
Scopus ID2-s2.0-105026016156
Erişim🔓 Açık Erişim
Özet
Background/Objectives: The aim of this study was to determine the plasma and muscle pharmacokinetics of ceftriaxone (25 mg/kg) in tilapia after different administration routes. Methods: Two hundred and sixteen fish maintained at 30 ± 1.5 °C were divided equally into three treatment groups: intravascular (IV), intraperitoneal (IP), and intramuscular (IM). Ceftriaxone concentrations were quantified using high-performance liquid chromatography, and pharmacokinetic parameters were calculated by non-compartmental analysis. Results: The plasma total body clearance, volume of distribution at steady state, and elimination half-life (t<inf>1/2λz</inf>) were 0.22 L/h/kg, 0.85 L/kg, and 5.27 h, respectively. The t<inf>1/2λz</inf> values were comparable among the IV, IP, and IM injection groups. The peak plasma concentration was 37.71 ± 3.12 µg/mL and 40.51 ± 2.77 µg/mL following IP and IM injection, respectively. The bioavailability was 67.04% for IP and 101.48% for IM. The peak muscle concentration was 9.49 ± 0.75 µg/g for IV, 5.71 ± 0.85 µg/g for IP, and 12.24 ± 2.41 µg/g for IM injection. The AUC<inf>0–∞muscle</inf>/AUC<inf>0–∞plasma</inf> ratio was 0.23, 0.18, and 0.30 for the IV, IP, and IM groups, respectively. The AUC<inf>muscle</inf>/AUC<inf>plasma</inf> indicates the ratio of drug penetration into the muscle, and a value less than 1 indicates that ceftriaxone penetrates into muscle tissue at a low ratio. Conclusions: These results indicate that ceftriaxone is well absorbed after IP and IM injections and passes into muscle tissue at a low tissue penetration. Ceftriaxone can be administered via IP and IM injection in Nile tilapia; nevertheless, its therapeutic efficacy requires evaluation.
Yazarlar (11)
1
Pedro Marin
ORCID: 0000-0003-4849-4452
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
D. Durna Corum
4
Elena Badillo
ORCID: 0000-0003-0888-4851
5
María Teresa Yuste
ORCID: 0000-0002-9897-8140
6
Önder Yıldırım
7
Ertugrul Terzi
ORCID: 0000-0003-2811-6497
8
Ruby C. Gonzales
9
Dan M. Arriesgado
10
Victor R. Navarro
11
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
bioavailability
ceftriaxone
muscle
Nile tilapia
pharmacokinetic
Kurumlar
Kastamonu University
Kastamonu Turkey
Mindanao State University at Naawan
Naawan Philippines
Muğla Sıtkı Koçman Üniversitesi
Mugla Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Universidad de Murcia
Murcia Spain
University of Hatay Mustafa Kemal
Hatay Turkey