Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The Importance of Biomarkers in the Diagnosis and Follow-Up of Celiac Disease
Genel Tip Dergisi · Ekim 2023
YÖKSİS Kayıtları
THE İMPORTANCE OF BİOMARKERS İN THE DİAGNOSİS AND FOLLOW-UP OF CELİAC DİSEASE
Genel Tıp Dergisi · 2023 tr dizin, EBSCO
DOKTOR ÖĞRETİM ÜYESİ MELTEM GÜMÜŞ →
THE İMPORTANCE OF BİOMARKERS İN THE DİAGNOSİS AND FOLLOW-UP OF CELİAC DİSEASE
Genel Tıp Dergisi · 2023 tr dizin, EBSCO
PROFESÖR HALİL HALDUN EMİROĞLU →
Makale Bilgileri
DergiGenel Tip Dergisi
Yayın TarihiEkim 2023
Cilt / Sayfa33 · 548-557
Scopus ID2-s2.0-105009384917
Erişim🔓 Açık Erişim
Özet
Aim: In the present study, the purpose is to investigate the clinical significance, diagnostic capabilities, relationships, and correlations of inflammation-based biomarkers before and after treatment in children with Celiac Disease. Methods: The study was conducted by retrospectively evaluating the files of patients who were diagnosed and followed up in the Department of Pediatric Gastroenterology of Selcuk University between January 2011 and January 2023. The study was completed with 202 Celiac Disease patients who were diagnosed according to the criteria of the European Pediatric Gastroenterology, Hepatology, and Nutrition Community and 160 healthy follow-ups. In case of clinical or laboratory suspicion, serological tests such as positive Tissue Transglutaminase Antibody and Anti-Endomysium values and the histopathological examination of the endoscopic tissue sample findings consistent with Celiac Disease were evaluated. Results: There were 122 (56.7%) girls and 80 (54.4%) boys in the patient group and 93 (43.3%) girls and 67 (45.6%) boys in the control group. The most common intestinal complaint was abdominal pain in 49 (22.3%) patients. Gluten-free diet treatment was started after the diagnosis. The values of the patients at the time of diagnosis, in the 6th month after the diet, and the values of healthy control patients were compared. A weak and positive correlation was found between NLR, RPR, RLR levels, and age, body weight, and height in the correlation analysis. The ROC curve for hematological biomarkers was used to evaluate the level of additional diagnostic support in Celiac Disease patients. Conclusion: After a gluten-free diet, symptoms regress, and the development of more serious celiac-related damage can be prevented. This suggests that NLR, RLR, PLR, SII, HRR, and PNI formulas, which are used in many inflammatory conditions and obtained from routine hemogram parameters, can be used to determine dietary compliance in Celiac Disease patients during their follow-ups.
Yazarlar (6)
1
Meltem Gumus
2
Alaaddin Yorulmaz
3
Esra Kilim
ORCID: 0009-0000-3988-4788
4
Reyhan Kaya
ORCID: 0000-0001-5813-4448
5
Anna Carina Ergani
6
Halil Haldun Emiroğlu
Anahtar Kelimeler
Biomarker
Celiac disease
Children
Gluten-free diet
Kurumlar
Kilis Prof. Dr. Alaeddin Yavaşca State Hospital
Kilis Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Health Sciences
Istanbul Turkey