Scopus
YÖKSİS Eşleşti
Neuroprotective role of curcumin on the hippocampus against the oxidative stress and inflammation of streptozotocin-induced diabetes in rats
Metabolic Brain Disease · Ocak 2025
YÖKSİS Kayıtları
Neuroprotective role of curcumin on the hippocampus against the oxidative stress and inflammation of streptozotocin-induced diabetes in rats
Metabolic Brain Disease · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ ÜLKÜ SAYGILI DÜZOVA →
Neuroprotective role of curcumin on the hippocampus against the oxidative stress and inflammation of streptozotocin-induced diabetes in rats
METABOLIC BRAIN DISEASE · 2025 SSCI
PROFESÖR NURCAN DÖNMEZ →
Makale Bilgileri
DergiMetabolic Brain Disease
Yayın TarihiOcak 2025
Cilt / Sayfa40
Scopus ID2-s2.0-85209711932
Özet
In recent years, it has gained importance to determine the effects of diabetes on central nervous system complications. This study aimed to assess the neuroprotective properties of curcumin against neuronal damage in the rat hippocampus caused by diabetes. In accordance with this purpose, we investigated the effects of curcumin on oxidative/antioxidative parameters and pro-inflammatory cytokines in the hippocampal tissue of diabetic Wistar rats. For this purpose, 32 adults, male and healthy Wistar Albino rats were used. Animals were randomly divided into four separate groups: control (C), curcumin(Cu), diabetes (D) and Diabetes + Curcumin (DCu)-treated groups. 60 mg/kg STZ i.p. A single dose was administered to D and DCu groups. Cu and DCu groups were given 50 mg/kg/day curcumin by gavage. After four weeks of treatment, the animals were decapitated under anesthesia and tissue samples were taken for analyses of the parameters (TNF-α, IL-6, IL-1, IL-10, MDA, SOD, catalase, and GSH activities) in the hippocampal tissue. TNF-α, IL-6, IL-1, and MDA levels were increased significantly (p < 0.05) in rats with diabetes compared to the other three groups. TNF-α, IL-6, IL-1, and MDA levels were lower in DCu group animals compared to the D group. It was determined that IL-10, SOD, Catalase, and GSH levels, which were significantly decreased in the D group, increased in the curcumin-supplemented diabetic group (DCu). The relevant sentence has been changed as follows. In conclusion, our findings from this study prove the protective effect of curcumin against diabetes-induced neuropathy in the hippocampus in rats with STZ-induced diabetes.
Yazarlar (3)
1
M. Özsan
2
Ülkü Saygili Düzova
ORCID: 0000-0001-8402-0022
3
Nurcan Dönmez
Anahtar Kelimeler
Curcumin
Cytokines
Diabetes
Hippocampus
Inflammation
Oxidative stress
Kurumlar
Niğde Ömer Halisdemir University
Nigde Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
5
Atıf
3
Yazar
6
Anahtar Kelime