Scopus
🔓 Açık Erişim
Pre-earthquake kidney function is a predictor of outcomes in earthquake-related crush syndrome
BMC Nephrology · Aralık 2025
Makale Bilgileri
DergiBMC Nephrology
Yayın TarihiAralık 2025
Cilt / Sayfa26
Scopus ID2-s2.0-105007552746
Erişim🔓 Açık Erişim
Özet
Background: The devastating earthquakes in Kahramanmaraş, Türkiye, in February 2024, caused extensive trauma and loss of lives, causing unique challenges in the management of earthquake-related crush syndrome. The current study investigates the prognostic value of pre-earthquake kidney function for mortality prediction in patients diagnosed with crush syndrome. Methods: A multi-center retrospective analysis was performed using data from 469 patients treated at 46 nephrology clinics. Pre-earthquake Kidney function, defined by serum creatinine and estimated glomerular filtration rate (eGFR) levels, was obtained from pre-earthquake health records. Clinical findings, laboratory parameters, complications, and survival probabilities were analyzed. Multivariate Cox regression was used to identify independent predictors of in-hospital mortality. Results: The mean age of participants was 42.56 ± 16.92 years (Non-survivors: 50.46 ± 20.03 years, Survivors: 42.34 ± 16.80 years (p = 0.172)). The in-hospital mortality rate was 2.8%. Non-survivors exhibited significantly higher pre-earthquake creatinine levels than survivors (1.04 ± 0.61 mg/dL vs. 0.77 ± 0.33 mg/dL, p = 0.03), with lower eGFR (85.2 ± 34.7 mL/min/1.73 m² vs. 115.8 ± 39.4 mL/min/1.73 m², p = 0.008). Compared with survivors, non-survivors had higher incidences of AKI (92.3% vs. 61.6%, p = 0.037) and more severe metabolic disturbances, including hyperkalemia (5.41 ± 1.72 mmol/L vs. 5.13 ± 0.98 mmol/L, p = 0.008). Regression analysis revealed that pre-earthquake creatinine (HR: 9.121, 95% CI: 2.686–30.970, p < 0.001) and potassium levels at admission (HR: 3.338, 95% CI: 1.540–7.232, p = 0.002) were independent predictors of mortality. Conclusions: Pre-earthquake kidney function significantly predicts mortality in crush syndrome patients, highlighting the importance of baseline kidney assessment in disaster preparedness.
Yazarlar (46)
1
Ramazan Danis
ORCID: 0000-0001-7493-7179
2
Savas Ozturk
ORCID: 0000-0002-0961-3810
3
Ismail Kocyigit
ORCID: 0000-0002-6654-4727
4
Jehat Kılıç
ORCID: 0000-0003-3722-350X
5
Merve Civan
ORCID: 0000-0002-6776-369X
6
Tuncay Sahutoglu
ORCID: 0000-0003-2015-4421
7
Dilek Torun
ORCID: 0000-0002-6267-3695
8
Engin Onan
ORCID: 0000-0003-1299-229X
9
Ahmet Alper Kıykım
ORCID: 0000-0001-9922-9267
10
Simal Köksal Cevher
ORCID: 0000-0001-6502-2399
11
Gursel Yildiz
ORCID: 0000-0002-2445-1477
12
Zeynep Ebru Eser
ORCID: 0000-0001-7559-8973
13
Fatma Betül Güzel
ORCID: 0000-0003-1569-9654
14
Suleyman Karakose
ORCID: 0000-0003-4680-7435
15
Tolga Yildirim
ORCID: 0000-0001-7972-8317
16
Mehmet Polat
ORCID: 0000-0003-1952-4237
17
Ebru Gök Oğuz
ORCID: 0000-0002-2606-3865
18
Ali Gurel
ORCID: 0000-0001-8087-8814
19
Yasemin Coşkun Yavuz
ORCID: 0000-0003-1733-9003
20
Hasan Kayabaşı
ORCID: 0000-0003-2754-5687
21
Zehra Eren
ORCID: 0000-0003-4871-3416
22
Mehmet Riza Altiparmak
ORCID: 0000-0002-3579-1100
23
Nurhan Seyahi
ORCID: 0000-0001-7427-618X
24
Mehmet Kucuksu
ORCID: 0000-0002-6646-2625
25
Sibel Gokcay Bek
ORCID: 0000-0003-3325-5993
26
Esra Akcali
ORCID: 0000-0003-0946-0823
27
Irem Pembegul
ORCID: 0000-0002-4609-1580
28
Zeki Aydin
ORCID: 0000-0001-8389-8271
29
Elif Arı Bakır
ORCID: 0000-0001-9208-7972
30
Saliha Yildirim
ORCID: 0000-0002-2693-1167
31
Sabahat Ecder
ORCID: 0000-0003-2631-6532
32
Mehmet Horoz
ORCID: 0000-0003-3400-9583
33
Funda Sarı
34
Yavuz Ayar
ORCID: 0000-0003-4607-9220
35
Murat Tugcu
ORCID: 0000-0002-5307-050X
36
Ayça İnci
ORCID: 0000-0002-7894-8913
37
Numan Gorgulu
ORCID: 0000-0003-3776-885X
38
Nedim Yılmaz Selçuk
ORCID: 0000-0002-6853-0863
39
Gulizar Sahin
ORCID: 0000-0002-0409-2710
40
Cuma Bülent Gül
ORCID: 0000-0003-2467-9356
41
Hamat Dheir
ORCID: 0000-0002-3569-6269
42
Özdem Kavraz
ORCID: 0000-0003-4697-2799
43
Abdülkadir Ünsal
ORCID: 0000-0003-4074-1084
44
Sedat Üstündağ
ORCID: 0000-0002-8502-9181
45
Ali Rıza Odabaş
ORCID: 0000-0002-5248-1390
46
Serhan Tuglular
ORCID: 0000-0002-6384-1697
Anahtar Kelimeler
acute kidney injury
Crush syndrome
disaster nephrology
hyperkalemia
kidney function
mortality
Türkiye
Kurumlar
Akdeniz Üniversitesi
Antalya Turkey
Alanya Alaaddin Keykubat University
Alanya Turkey
Antalya Training and Research Hospital
Antalya Turkey
Başkent Üniversitesi
Ankara Turkey
Bursa Uludağ Üniversitesi
Bursa Turkey
Depatment of İnternet Medicine
Istanbul Turkey
Erciyes Üniversitesi
Kayseri Turkey
Fethi Sekin City Hospital
Elazig Turkey
Firat Üniversitesi
Elazig Turkey
Gazi Üniversitesi
Ankara Turkey
Gazi Yasargil Education and Research Hospital
Diyarbakir Turkey
Giresun Üniversitesi
Giresun Turkey
Hacettepe Üniversitesi
Ankara Turkey
Istanbul Üniversitesi
Istanbul Turkey
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine
Istanbul Turkey
Kartal Lutfi Kirdar City Hospital
Istanbul Turkey
Kayseri City Hospital
Kayseri Türkiye
Kilis State Hospital
Kilis Turkey
Kocaeli Üniversitesi
İzmit Turkey
Malatya Turgut Ozal University
Malatya Turkey
Marmara Üniversitesi Tip Fakültesi
Istanbul Turkey
Medeniyet University
Istanbul Turkey
Mehmet Akif Inan Training and Research Hospital
Sanliurfa Turkey
Mersin City Training and Research Hospital
Mersin Turkey
Mersin Üniversitesi
Mersin Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Nevşehir State Hospital
Nevsehir Turkey
Sakarya Üniversitesi
Serdivan Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Sisli Hamidiye Etfal Education and Research Hospital
Istanbul Turkey
T. C. Sağlık Bakanlığı, Mersin Devlet Hastanesi
Mersin Turkey
Trakya University, Faculty of Medicine
Edirne Turkey
University of Health Sciences
Istanbul Turkey