Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Associations of standard and extended high-frequency thresholds with suprathreshold auditory brainstem response morphology in normal-hearing adults
Hearing Research · Mart 2026
YÖKSİS Kayıtları
Associations of Standard and Extended High-Frequency Thresholds with Suprathreshold Auditory Brainstem Response Morphology in Normal-Hearing Adults
Hearing Research · 2026 SCI-Expanded
Dr. Öğr. Üyesi BÜŞRA KAYNAKOĞLU →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Associations of Standard and Extended High-Frequency Thresholds with Suprathreshold Auditory Brainstem Response Morphology in Normal-Hearing Adults
2026 ISSN: 0378-5955 SCI-Expanded Q1
Dr. Öğr. Üyesi BÜŞRA KAYNAKOĞLU →
Makale Bilgileri
Dergi
Hearing Research
ISSN03785955
Yayın TarihiMart 2026
Cilt / Sayfa473
Scopus ID2-s2.0-105029769828
Özet
The Auditory Brainstem Response (ABR) is essential for assessing neural integrity, yet the influence of subclinical extended high-frequency (EHF) deficits on waveform morphology remains insufficiently characterized. This cross-sectional study evaluated the distinct predictive utility of Global Standard Averages (0.125–8 kHz) versus EHF thresholds (9–20 kHz) for ABR latencies and amplitudes in 89 otologically healthy adults. While all but one participants exhibited clinically normal hearing thresholds (≤20 dB HL) across standard frequencies, multiple linear regression analyses were employed to identify independent predictors of neural synchrony and transmission timing, controlling for age and sex. Results indicated a functional dissociation between peripheral magnitude and central timing predictors. Even after adjustment for covariates, EHF averages remained a significant independent predictor of Wave I amplitude (β = -0.28, p = .015), underscoring the critical link between basal cochlear status and distal neural synchrony. Conversely, Wave V latency was primarily predicted by biological sex (β = -0.30, p = .006) and standard high-frequency sensitivity (4–8 kHz) rather than ultra-high frequencies. Additionally, analyses of the Wave V/I amplitude ratio did not demonstrate expected age-related central gain, likely due to the cohort's preserved peripheral integrity. Collectively, these findings suggest that EHF sensitivity serves as a superior marker for distal auditory nerve integrity compared to standard measures. Consequently, incorporating EHF audiometry into diagnostic protocols offers enhanced sensitivity for detecting subclinical cochlear deficits that evade capture by standard audiometric batteries.
Yazarlar (3)
1
İrem Sendesen
2
Büşra Kaynakoğlu
ORCID: 0000-0003-0528-1086
3
Eser Sendesen
Anahtar Kelimeler
Auditory brainstem response
Cochlear synaptopathy
Extended high-frequency audiometry
Wave I amplitude
Wave V latency
Kurumlar
Gazi Üniversitesi
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Hearing Research
Q2
SJR Skoru0,891
H-Index145
YayıncıElsevier B.V.
ÜlkeNetherlands
Sensory Systems (Q2)