Scopus
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EVALUATION OF SERUM HOMOCYSTEINE AND ASYMMETRIC DIMETHYLARGININE LEVELS IN PATIENTS WITH AUTOIMMUNE THYROID DISEASE
Acta Clinica Croatica · Eylül 2025
YÖKSİS Kayıtları
EVALUATION OF SERUM HOMOCYSTEINE AND ASYMMETRIC DIMETHYLARGININE LEVELS IN PATIENTS WITH AUTOIMMUNE THYROID DISEASE
ACTA CLINICA CROATICA · 2025 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Makale Bilgileri
DergiActa Clinica Croatica
Yayın TarihiEylül 2025
Cilt / Sayfa64 · 550-560
Scopus ID2-s2.0-105029290654
Erişim🔓 Açık Erişim
Özet
Autoimmune thyroid diseases (AITD) may lead to increased cardiovascular risk; however, the underlying mechanism for this is unclear. The aim of our study was to investigate serum asymmetric dimethylarginine (ADMA), vitamin B12, folic acid and homocysteine (HCY) levels in patients with and without AITD. A total of 180 individuals were enrolled in this study, encompassing 45 patients with Hashimoto’s Thyroiditis (HT), 45 patients with Graves’ disease (GD), 45 individuals with multinodular goiter (MNG) and 45 healthy controls who were admitted to Selçuk University Medical Faculty’s Department of Endocrinology. All statistical analyses were conducted using the R Statistical Software (version 4.2.1). We found increased levels of HCY and ADMA, and decreased levels of folic acid in AITD compared to the control group (P=0.021, P=0.04 and P=0.017, respectively). Vitamin B12 levels were similar between groups. HCY was negatively correlated with vitamin B12 and folic acid (r=-0.028, P=0.002 and r=-0.368, P < 0.001, respectively). Our study revealed that a rise in ADMA and HCY levels in patients with AITD can provide insight into how AITD may contribute to endothelial dysfunction and cardiovascular risks.
Yazarlar (10)
1
Esra Paydas Hataysal
ORCID: 0000-0002-3538-8135
2
M. K. Korez
ORCID: 0000-0001-9524-6115
3
Fatma Sengul
4
Hüsamettin Vatansev
5
Emel Şahin
6
Cem Onur Kirac
7
Levent Kebapcilar
8
Suleyman Hilmi Ipekci
ORCID: 0000-0003-4410-2212
9
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
10
Ali Ünlü
ORCID: 0000-0002-9991-3939
Anahtar Kelimeler
Asymmetric dimethylarginine
Graves’ disease
Hashimoto disease
Homocysteine
Kurumlar
Adiyaman Üniversitesi
Adiyaman Turkey
Goztepe Prof. Dr. Suleyman Yalcin City Hospital
Istanbul Turkey
İstanbul Atlas Üniversitesi
Istanbul Turkey
Medova Hospital
Konya Turkey
Necip Fazil City Hospital
Kahramanmaras Turkey
Osmaniye State Hospital
Osmaniye Turkey
Selçuk Tip Fakültesi
Konya Turkey