Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
Evaluation of ADMA and Galectin 3 Levels in Predicting Cardiovascular Disease Risk in Patients with Bipolar Disorder
Genel Tip Dergisi · Ekim 2025
YÖKSİS Kayıtları
Evaluation of ADMA and Galectin 3 Levels in Predicting Cardiovascular Disease Risk in Patients with Bipolar Disorder
Genel Tıp Dergisi · 2025 TR DİZİN
Prof. Dr. SEDAT ABUŞOĞLU →
Makale Bilgileri
Dergi
Genel Tip Dergisi
Yayın TarihiEkim 2025
Cilt / Sayfa35 · 796-804
Scopus ID2-s2.0-105024122885
Erişim🔓 Açık Erişim
Özet
Aim: Bipolar disorder (bp), a chronic disease, occurs in 1-5% of the population. BP patients have approximately twice as many cardiovascular disease (CVD)-related deaths than the general population. Asymmetric Dimethylarginine (ADMA) and Galectin 3 (Gal 3) can be biomarkers for determining CVD risk and the burden of chronic diseases. Myocardial performance index (MPl) is an echocardiographic parameter evaluating left ventricular (lv) systolic and diastolic functions. MPl also indicates CVD mortality risks. This study aims to investigate the relationship between the sociodemographic and disease-related characteristics of BP patients and the parameters evaluating CVD risks and chronic diseases. Material and Methods: ADMA and N(G)-monomethyl L-arginine (L-NMMA) were measured from the sera from 75 BP patients admitted to Mazhar Osman Mood Center, Faculty of Medicine at Selcuk University and who were euthymic for at least 8 weeks. Simultaneously, echocardiography (ECG) was performed to obtain information about cardiac function. Results: The study included 75 BP patients (52%, n=39 female; 48%, n=36 male). While 54.9% (n=39) had previously experienced psychotic symptoms, 45.1% (n=32) experienced no previous psychotic symptoms, and half had BP family members. Mean plasma ADMA values were 0.26 0.10 pm/L, the mean MPl values were 0.33 0.77, and the mean Gal 3 value was 895.66 721.29 pg/mL. There is a moderately significant positive correlation between age and MPl values (r=0.588, p *0.001). There was a moderately significant negative correlation between age and Gal 3 values (r=-0.493, p*0.001). No significant correlation was found between age and ADMA values. No statistically significant difference was observed in mean values of MPl, ADMA, and Gal 3 concerning the presence of psychotic symptoms. Conclusion: No significant relationship was found between ADMA determining CVD risk, disease burden, and psychotic symptoms in BP patients. BP is a chronic disease and its episodic course increases with age and the increase in MPI and Gal 3 are consistent with the literature.
Yazarlar (4)
1
Gökçe Kavak Sinanoğlu
ORCID: 0000-0003-4786-2110
2
Kürşat Altınbaş
3
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
4
Kenan Erdem
Anahtar Kelimeler
ADMA
bipolar disorder
cardiovascular risk galectin 3
myocardial perfusion
Kurumlar
ALKU Alanya Education and Research Hospital
Antalva Turkey
İstanbul Atlas Üniversitesi
Istanbul Turkey
Selçuk Tip Fakültesi
Konya Turkey