Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q1
Molecular and Biochemical Comparison of Various Rat Models for Experimental Diabetes Induction
Pakistan Veterinary Journal · Ocak 2025
YÖKSİS Kayıtları
Molecular and Biochemical Comparison of Various Rat Models for Experimental Diabetes
Induction
The Pakistan Veterinary Journal · 2025 SCI-Expanded
Arş. Gör. FATMA GÖKTÜRK →
Molecular and Biochemical Comparison of Various Rat Models for Experimental Diabetes
Induction
The Pakistan Veterinary Journal · 2025 SCI-Expanded
Arş. Gör. FATMA GÖKTÜRK →
Molecular and Biochemical Comparison of Various Rat Models for Experimental Diabetes
Induction
The Pakistan Veterinary Journal · 2025 SCI-Expanded
Prof. Dr. BURAK DİK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Clinical Comparison of Medetomidine with Isoflurane or Sevoflurane for Anesthesia in Horses
2015 ISSN: 0253-8318 SSCI
Prof. Dr. MUSTAFA ARICAN →
Bacillus anthracis isolated from a dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
A Retrospective Study of Fractures in Neonatal Calves 181 Cases 2002 2012
2013 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. KURTULUŞ PARLAK →
Effect of Different Storage Temperatures on the Stability of Bovine Viral Diarrhea Virus BVDV RNA in Blood Samples
2015 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. IRMAK DİK →
The investigation of bovine viral diarrhoea virus antigens with immunofluorescence and immunohistochemical methods in bovine abortions
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Effect of different storage temperatures on the stability of bovine viral diarrhea virus RNA in blood samples
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ATİLLA ŞİMŞEK →
Effect of Different Storage Temperatures on the Stability of Bovine Viral Diarrhea Virus BVDV RNA in Blood Samples
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. SİBEL YAVRU →
Bacillus anthracis Isolated from a Dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. OSMAN ERGANİŞ →
Bacillus anthracis Isolated from a Dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Doç. Dr. ASLI BALEVİ →
Genotypic Characterization of Bordetella bronchiseptica Strains Isolated from Stray and PetDogs
2016 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. UÇKUN SAİT UÇAN →
Quantification of mitral regurgitation in Anatolian Shepherd Dogs with aseymtomatic degenerative mitral valve disease
2016 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. HASAN GÜZELBEKTEŞ →
Genotypic Characterization of Bordetella bronchiseptica Strains Isolated from Stray and Pet Dogs
2016 ISSN: 0253-8318 SCI-Expanded
Doç. Dr. ASLI BALEVİ →
In Vitro Activity of Toxin Binders on Aflatoxin B1 in Poultry Gastrointestinal Medium
2018 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. HALİS UĞUZ →
Digit Bones (Acropodium) of Gazella (Gazella subgutturosa); Three-Dimensional Modelling
and Morphometry
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. MUSTAFA ORHUN DAYAN →
Predominancy of Rhipicephalus turanicus in Tick-infested Sheep from Turkey: a Large-scale Survey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. ALİ USLU →
Serological Investigation of Some Vector-Borne Parasitic and Rickettsial Agents in Dogs in the Western Part of Turkey
2021 ISSN: 0253-8318 SCI-Expanded Q1
Doç. Dr. ALİ USLU →
Serological Investigation of Some Vector-Borne Parasitic and Rickettsial Agents in Dogs in the Western Part of Turkey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. FERDA SEVİNÇ →
Predominancy of Rhipicephalus turanicus in Tick-infested Sheep from Turkey: a Large-scale Survey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. FERDA SEVİNÇ →
Digit Bones (Acropodium) of Gazella (Gazella subgutturosa); Three-Dimensional Modelling and Morphometry
2021 ISSN: 0253-8318 SCI-Expanded Q3
Dr. Öğr. Üyesi SEDAT AYDOĞDU →
Makale Bilgileri
ISSN02538318
Yayın TarihiOcak 2025
Cilt / Sayfa45 · 1972-1979
Scopus ID2-s2.0-105028491992
Erişim🔓 Açık Erişim
Özet
The study aimed to compare three different experimental type 2 diabetes mellitus (T2DM) models performed on rats. 3 equal groups of 54 Wistar albino rats were randomly categorized as follows; first group: The rats treated by high-fat diet and streptozotocin 35mg/kg, SC), second group: The rats received drinking water containing 20% fructose, and third group: Nicotinamide (110 mg/kg, IP) and streptozotocin (60 mg/kg, SC) were administered. Six animals from each group were euthanized at 6, 10 and 12 weeks to evaluate the diabetic process in the models. Glucose and HbA1c levels tended to be higher in the third model, though overall profiles were comparable to first model group. In the early phases, the first model group's triglyceride levels were statistically greater than those of the other groups, and its insulin levels dropped over time. The GLUT4, IRS1 and PIK3R expressions in skeletal muscle decreased in the first and third model groups. Based on practical considerations, the third model appeared to be more feasible for longterm studies and showed a better reflection of the T2DM phenotype; however, the first model demonstrated more pronounced effects in the short-term. The findings of this research may provide valuable insights for future studies by guiding researchers in selecting the appropriate experimental model for T2DM research in rats and will be a guide for developing new drugs and treatments in the search.
Yazarlar (5)
1
Burak Dik
2
Dudu Erkoc-Kaya
ORCID: 0000-0003-0114-6602
3
T. M. Parlak
4
Oznur Tufan
5
Fatma Gokturk
Anahtar Kelimeler
Experimental
Fructose
High-Fat Diet
Streptozotocin-Nicotinamide
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Pakistan Veterinary Journal
Q1
OA
SJR Skoru0,845
H-Index44
YayıncıUniversity of Agriculture
ÜlkePakistan
Veterinary (miscellaneous) (Q1)