Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Molecular and Biochemical Comparison of Various Rat Models for Experimental Diabetes Induction
Pakistan Veterinary Journal · Ocak 2025
YÖKSİS Kayıtları
Molecular and Biochemical Comparison of Various Rat Models for Experimental Diabetes
Induction
The Pakistan Veterinary Journal · 2025 SCI-Expanded
PROFESÖR BURAK DİK →
Makale Bilgileri
DergiPakistan Veterinary Journal
Yayın TarihiOcak 2025
Cilt / Sayfa45 · 1972-1979
Scopus ID2-s2.0-105028491992
Erişim🔓 Açık Erişim
Özet
The study aimed to compare three different experimental type 2 diabetes mellitus (T2DM) models performed on rats. 3 equal groups of 54 Wistar albino rats were randomly categorized as follows; first group: The rats treated by high-fat diet and streptozotocin 35mg/kg, SC), second group: The rats received drinking water containing 20% fructose, and third group: Nicotinamide (110 mg/kg, IP) and streptozotocin (60 mg/kg, SC) were administered. Six animals from each group were euthanized at 6, 10 and 12 weeks to evaluate the diabetic process in the models. Glucose and HbA1c levels tended to be higher in the third model, though overall profiles were comparable to first model group. In the early phases, the first model group's triglyceride levels were statistically greater than those of the other groups, and its insulin levels dropped over time. The GLUT4, IRS1 and PIK3R expressions in skeletal muscle decreased in the first and third model groups. Based on practical considerations, the third model appeared to be more feasible for longterm studies and showed a better reflection of the T2DM phenotype; however, the first model demonstrated more pronounced effects in the short-term. The findings of this research may provide valuable insights for future studies by guiding researchers in selecting the appropriate experimental model for T2DM research in rats and will be a guide for developing new drugs and treatments in the search.
Yazarlar (5)
1
Burak Dik
2
Dudu Erkoc-Kaya
ORCID: 0000-0003-0114-6602
3
T. M. Parlak
4
Oznur Tufan
5
Fatma Gokturk
Anahtar Kelimeler
Experimental
Fructose
High-Fat Diet
Streptozotocin-Nicotinamide
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey