Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Development and Characterization of a Fixed-Dose Orodispersible Film of Telmisartan and Indapamide for Enhancing Dissolution
Fabad Journal of Pharmaceutical Sciences · Ekim 2025
YÖKSİS Kayıtları
Development and Characterization of a Fixed-Dose Orodispersible Film of Telmisartan and Indapamide for Enhancing Dissolution
Fabad Journal of Pharmaceutical Sciences · 2025 TR DİZİN
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Development and Characterization of a Fixed-Dose Orodispersible Film of Telmisartan and Indapamide for Enhancing Dissolution
Fabad Journal of Pharmaceutical Sciences · 2025 TR DİZİN
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Intranasal Delivery of Nicotine Via Thermoresponsive Hydrogel Systems: Design, Characterization, And In Vitro Evaluation
2026 ISSN: 1300-4182 TR DİZİN
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Parasite-Derived MicroRNAs: Potential Alternative Targets for Laboratory Diagnosis of Cystic Echinococcosis
2023 ISSN: 1300-4182 SCOPUS
Prof. Dr. SALİH MAÇİN →
In vitro Evaluation of the Effects of Inula viscosa’s Different Extracts on Wound Healing and Oxidative Stress in Mouse L929 Fibroblast Cell Line
2024 ISSN: 1300-4182 scopus
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Development and Characterization of a Fixed-Dose Orodispersible Film of Telmisartan and Indapamide for Enhancing Dissolution
2025 ISSN: 1300-4182 TR DİZİN
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Development and Characterization of a Fixed-Dose Orodispersible Film of Telmisartan and Indapamide for Enhancing Dissolution
2025 ISSN: 1300-4182 TR DİZİN
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Makale Bilgileri
ISSN13004182
Yayın TarihiEkim 2025
Cilt / Sayfa50 · 513-530
Scopus ID2-s2.0-105026927106
Erişim🔓 Açık Erişim
Özet
Fixed-dose combination (FDC) of antihypertensive drugs improves efficacy, safety and patient adherence over monotherapy. However, an FDC of telmisartan (TEL) and indapamide (IND), both poorly soluble BCS Class II drugs, has not been available yet. This study aimed to develop an orodispersible film (ODF) containing TEL and IND cyclodextrin (CD) inclusion complexes (ICs) to enhance solubility and improve patient adherence. In the first phase of the study, phase-solubility analysis was performed with β-CD, then the ICs were prepared via kneading and assessed for solubility enhancement and entrapment efficiency. In the second phase, ICs were incorporated into hydroxypropyl-methylcellulose (HPMC) based ODFs using solvent casting. The films were characterized for thickness, mass, and content uniformity, surface pH, water content, folding endurance, Young’s modulus, FTIR, in vitro disintegration, and dissolution. AL-type phase-solubility plots confirmed 1:1 complexation and enhanced solubility by 1.7–4.1 fold, with entrapment efficiency >95%. ICs-loaded ODFs were thin (0.138 mm), uniform in mass (236.39 mg) and content (TEL 97.22%, IND 102.09%), nearly neutral pH, and low in water (2.68%). Mechanical testing showed adequate flexibility and stiffness (100 N/mm² modulus). Disintegration occurred in <35 s. Dissolution exceeded 90% for both drugs within 15 minutes in 6.8 phosphate buffer, whereas in 0.1N HCl, TEL showed complete release in 15 minutes and IND reached 97% after 20 minutes. In conclusion, TEL and IND ICs–loaded HPMC ODFs successfully overcame solubility limitations, offering an immediate-release formulation across the gastrointestinal pH range with favorable physicochemical properties and potential to improve patient adherence.
Yazarlar (4)
1
Dilara Orgul
2
Aslı Yi̇gi̇t
ORCID: 0009-0005-7345-6070
3
Yakup Gultekin
4
Sema Arisoy
ORCID: 0000-0003-2798-1884
Anahtar Kelimeler
Cyclodextrin
Fixed-Dose Combinations
Indapamide
Orodispensible Film
Solubility Enhancement
Telmisartan
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Fabad Journal of Pharmaceutical Sciences
Q3
SJR Skoru0,211
H-Index23
YayıncıSociety of Pharmaceutical Sciences of Ankara (FABAD)
ÜlkeTurkey
Pharmaceutical Science (Q3)