Scopus
🔓 Açık Erişim
Impact of Cadmium on Prostate-Specific Antigen and Endothelial Markers: A Risk for Prostatic Damage
Toxics · Aralık 2025
Makale Bilgileri
DergiToxics
Yayın TarihiAralık 2025
Cilt / Sayfa13
Scopus ID2-s2.0-105025921276
Erişim🔓 Açık Erişim
Özet
Cadmium (Cd) is a persistent toxic metal that bioaccumulates in human tissues and may disrupt redox and endocrine pathways, yet the metabolic mechanisms linking Cd exposure to both endothelial and prostate dysfunctions remain insufficiently defined. This study investigated whether chronic occupational Cd exposure alters methylated arginine metabolism and prostate-specific antigen (PSA) levels, indicating a shared toxicometabolic axis. A total of 150 male workers were enrolled, including 75 metallurgical employees with documented Cd exposure and 75 matched controls. All participants were non-smokers, eliminating confounding from tobacco-related oxidative or endocrine effects. Urinary Cd concentrations were quantified using Inductively Coupled Plasma–Mass Spectrometry (ICP–MS), and serum asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), L-arginine, citrulline, and PSA were measured by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) and electrochemiluminescence. The use of Inductively Coupled Plasma–Mass Spectrometry for cadmium quantification and LC-MS/MS for methylated arginine profiling provided high analytical specificity and sensitivity, strengthening the validity of biomarker measurements. Correlation and multivariable analyses adjusted for age and body mass index. Cd-exposed workers demonstrated significantly elevated urinary Cd, PSA, ADMA, and SDMA levels, alongside reduced arginine/ADMA ratios, consistent with impaired nitric oxide bioavailability. Urinary Cd strongly correlated with PSA and ADMA levels. These findings indicate that Cd may disrupt the nitric oxide pathway and elevates PSA, supporting a mechanistic link between vascular and prostate stress. Combined ADMA, SDMA, and PSA profiling may serve as an early biomarker panel for Cd-related metabolic injury in occupational settings.
Yazarlar (9)
1
Servet Birgin Iritas
2
Melih Gaffar Gözükara
ORCID: 0000-0002-6147-4053
3
Lutfiye Tutkun
4
Deniz Özkan Vardar
ORCID: 0000-0003-0976-9556
5
Murat Büyükşekerci
ORCID: 0000-0001-9921-0507
6
Gulsum Abusoglu
7
Serdar Deniz
8
Vugar Ali Turksoy
9
Engin Tutkun
ORCID: 0000-0003-2215-0424
Anahtar Kelimeler
ADMA
cadmium
endothelial dysfunction
nitric oxide
occupational exposure
PSA
SDMA
Kurumlar
Ankara Ataturk Research and Training Hospital
Ankara Türkiye
Ankara Yildirim Beyazit University
Ankara Turkey
Bozok Üniversitesi
Yozgat Turkey
Lokman Hekim Üniversitesi
Ankara Turkey
Malatya Turgut Ozal University
Malatya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
The Association of Industrial Toxicology and Occupational Hygiene
Ankara Turkey