Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
Effect of Low and High-Dose Dexamethasone on CYP3A and P-glycoprotein Expression and Function in Mice
Eurasian Journal of Veterinary Sciences · Ocak 2025
YÖKSİS Kayıtları
Effect of Low and High-Dose Dexamethasone on CYP3A and P-glycoprotein Expression and Function in Mice
Eurasian Journal of Veterinary Sciences · 2025 TR DİZİN
Dr. Öğr. Üyesi GONCA SÖNMEZ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Serological and virological investigation of bovine viral diarrhea virus infection in cattle with abortion problem
2013 ISSN: 1309-6958 ULAKBİM-YAŞAM BİLİMLERİ
Prof. Dr. OĞUZHAN AVCI →
Antibody prevalence against respiratory viruses in naturally infected cattle in Central Anatolia
2014 ISSN: 1309-6958 ULAKBİM-YAŞAM BİLİMLERİ
Prof. Dr. OĞUZHAN AVCI →
Disseminated metastatic transmissible venereal tumour in a bitch
2013 ISSN: 1309-6958 TR DİZİN 1 atıf
Prof. Dr. MEHMET MADEN →
Investigation on Listeria spp. in Patrige Meat
2014 ISSN: 1309-6958 ULAKBİM TR DİZİN, CAB Abstracts, Index Copernicus
Prof. Dr. GÜRKAN UÇAR →
Pastörize sıvı yumurta ile kabuklu yumurtanın bazı kalite özellikleri bakımından kıyaslanması
2015 ISSN: 1309-6958 ULAKBİM TR DİZİN, CAB Abstracts, Index Copernicus
Prof. Dr. AHMET GÜNER →
Barınak Köpeklerinde Canine Coronavirus Varlığının Belirlenmesi
2015 ISSN: 1309-6958 TR DİZİN
Doç. Dr. IRMAK DİK →
Microbiological quality of red meat pieces
2015 ISSN: 1309-6958 Türkiye Atıf Dizini *EBSCO-HOST*Cab Abstracts*Veterinary Bulletin*Veterinary Science Database*Index Veterinarius*Dairy Science Abstracts *Animal Breeding Abstracts*Agricultural Engineering Abstracts *Global Health*World Agricultural Economics and Rural Sociology Abstracts *Forest Products Abstracts
Prof. Dr. ÜMİT GÜRBÜZ →
Nerium Oleander Distilatının Antimikrobiyal Etkisinin Araştırılması
2013 ISSN: 1309-6958 TR DİZİN
Prof. Dr. BURAK DİK →
Doksorubisinin neden olduğu organ hasarlarında Nerium Oleander distilatının koruyucu etkinliğinin belirlenmesi
2014 ISSN: 1309-6958 TR DİZİN
Prof. Dr. BURAK DİK →
Koyunlarda Tarantula cubensis alkolik ekstraktının (Theranekron) serum tiyobarbitürik asit reaktif ürünlerine etkisi
2014 ISSN: 1309-6958 TR DİZİN
Prof. Dr. BURAK DİK →
Pathological and microbiological investigations on the lesions of the respiratory systems of laying hens
2008 ISSN: 1309-6958 *TÜBİTAK-ULAKBİM-YAŞAM BİLİMLERİ *Türkiye Atıf Dizini *EBSCO-HOST *Cab Abstracts *Veterinary Bulletin *Veterinary Science Database *Index Veterinarius *Dairy Science Abstracts *Animal Breeding Abstracts *Agricultural Engineering Abstracts *Global Health *World Agricultural Economics and Rural Sociology Abstracts *Forest Products Abstracts *Grasslands and Forage Abstracts *Helminthological Abstracts *Rural Development Abstracts *Soils and Fertilizers *Soybean Abstracts *Sugar Industry Abstracts *Tropical Disaeases Bulletin *Wheat, Barley and Tritacale Abstracts *Maize Abstracts
Prof. Dr. ÖZGÜR ÖZDEMİR →
The retrospective evaluations of the neoplastic cases of dog between 2006 to 2011
2013 ISSN: 1309-6958 *TÜBİTAK-ULAKBİM-YAŞAM BİLİMLERİ*Türkiye Atıf Dizini*EBSCO-HOST*Cab Abstracts*Veterinary Bulletin*Veterinary Science Database*Index Veterinarius*Dairy Science Abstracts*Animal Breeding Abstracts*Agricultural Engineering Abstracts*Global Health*World Agricultural Economics and Rural Sociology Abstracts*Forest Products Abstracts*Grasslands and Forage Abstracts*Helminthological Abstracts*Rural Development Abstracts*Soils and Fertilizers*Soybean Abstracts*Sugar Industry Abstracts*Tropical Disaeases Bulletin*Wheat, Barley and Tritacale Abstracts*Maize Abstracts
Prof. Dr. ÖZGÜR ÖZDEMİR →
Bir İnekte Melanom Olgusu
2006 ISSN: 1309-6958 *TÜBİTAK-ULAKBİM-YAŞAM BİLİMLERİ*Türkiye Atıf Dizini*EBSCO-HOST*Cab Abstracts*Veterinary Bulletin*Veterinary Science Database*Index Veterinarius*Dairy Science Abstracts*Animal Breeding Abstracts*Agricultural Engineering Abstracts*Global Health*World Agricultural Economics and Rural Sociology Abstracts*Forest Products Abstracts*Grasslands and Forage Abstracts*Helminthological Abstracts*Rural Development Abstracts*Soils and Fertilizers*Soybean Abstracts*Sugar Industry Abstracts*Tropical Disaeases Bulletin*Wheat, Barley and Tritacale Abstracts*Maize Abstracts
Prof. Dr. ÖZGÜR ÖZDEMİR →
Ham ayçiçek yağı yerine yan ürünlerinin yumurta tavuklarında enerji kaynağı olarak kullanımı
1994 ISSN: 1309 - 6958 TR DİZİN
Prof. Dr. TAHİR BALEVİ →
Serbest ve korunmuş formdaki asit yağın süt ineklerinde rumen fermentasyonu ve süt verimi üzerine etkileri
2000 ISSN: 1309 - 6958 TR DİZİN
Prof. Dr. HUZUR DERYA ARIK →
Geçiş dönemindeki süt ineklerinde gliserol kullanımının etkileri
2010 ISSN: 1309 - 6958 TR DİZİN
Prof. Dr. TAHİR BALEVİ →
Bazı et ürünlerinde E coli O157 H7 varlığının araştırılması
2010 ISSN: 1309-6958 EBSCO-HOST*Cab Abstracts*Veterinary Bulletin*Veterinary Science Database*Index Veterinarius 1 atıf
Prof. Dr. ÜMİT GÜRBÜZ →
Karaman ilinde yetiştirilen koyunlarda Blue Tongue Virus enfeksiyonunun serolojik olarak araştırılması
2015 ISSN: 1309-6958 TÜBİTAK Yaşam Bilimleri, CAB Abstracts, Vet Bull, EBSCO, Vet Sci Database vs...
Prof. Dr. ATİLLA ŞİMŞEK →
Yerli merkeplerde vena portae’nın karaciğer içerisindeki dağılımı üzerine makroanatomik araştırmalar
2014 ISSN: 1309-6958 Cab Abstract
Prof. Dr. MUSTAFA ORHUN DAYAN →
Makale Bilgileri
ISSN13096958
Yayın TarihiOcak 2025
Cilt / Sayfa41
Scopus ID2-s2.0-105026192334
Erişim🔓 Açık Erişim
Özet
Dexamethasone, which acts on nuclear receptors, is used together with P-gp and Cyp3a4 substrates at different doses in the treatment of diverse diseases. The aim of the study is to determine the effect of different doses of dexamethasone on the expressions and functions of P-gp and Cyp3a4 (mouse homologues of Cyp3a4 are Cyp3a11 and Cyp3a13). Animals (n=54) were divided into 9 equal groups. The control group was given only water. (The second group received fexofenadine, the third group received midazolam, the fourth group received low-dose dexamethasone, and the fifth group received high-dose dexamethasone. Low dose dexamethasone was administered to the sixth and seventh groups, and high dose dexamethasone was administered to the eighth and ninth groups.) 24 hours after these applications, fexofenadine was administered to the sixth and eighth groups, and midazolam was administered to the seventh and ninth groups. Synthesis of mdr1a, mdr1b, Cyp3a11 and Cyp3a13 in the small intestine and liver were determined using RT-qPCR. Plasma concentrations of fexofenadine and midazolam were determined using HPLC-UV. The effect of dexamethasone on Cyp3a11 expression was determined to be dose-related, while its effect on P-gp expression was not dose-related. Midazolam, a CYP3A substrate, did not cause P-gp induction in the small intestine, but did cause P-gp induction in the liver. Fexofenadine and midazolam reduced the effect of dexamethasone on Cyp3a11 expression in the small intestine. Dexamethasone dose-dependently decreased the plasma concentration of midazolam and increased that of its metabolite. Dexamethasone caused a dose-independent decrease in plasma concentrations of fexofenadine. The effect of dexamethasone on P-gp expression is not dose-dependent, but its effect on Cyp3a11 ve Cyp3a13 expression is dose-dependent. Fexofenadine and midazolam caused a reduction in the effect of dexamethasone on Cyp3a11 expression in the small intestine.
Yazarlar (7)
1
H. Eser Faki
2
Gonca Sönmez
3
B. Traş
4
Kamil Üney
ORCID: 0000-0002-8674-4873
5
T. M. Parlak
6
Zeynep Ozdemir Kutahya
7
Hakan Akbayrak
Anahtar Kelimeler
Cyp3a4
Dexamethasone
Dose
Mice
P-glycoprotein
Kurumlar
Çukurova Üniversitesi
Adana Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Eurasian Journal of Veterinary Sciences
Q4
OA
SJR Skoru0,178
H-Index5
YayıncıSelcuk Universitesi, Veteriner Fakultesi
ÜlkeTurkey
Veterinary (miscellaneous) (Q4)