Scopus
🔓 Açık Erişim
Multi-faceted bioactivity of three unexplored Turkish plants: A comparative phytochemical and pharmacological profiling
Fitoterapia · Mart 2026
Makale Bilgileri
DergiFitoterapia
Yayın TarihiMart 2026
Cilt / Sayfa189
Scopus ID2-s2.0-105026141450
Erişim🔓 Açık Erişim
Özet
Since ancient times, plants have been used as a valuable source for treating serious diseases. Three different plants, namely Aubrieta pinardii , Johrenia dichotoma , and Malabaila dasyantha were used and extracted using the extraction solvents ethyl acetate (EA), methanol (MeOH), and water. Antioxidant activity was determined using several in vitro assays. Subsequently, the enzyme inhibition activities of the extracts were evaluated against cholinesterases (AChE and BChE), tyrosinase, amylase, and glucosidase. The antibacterial and antifungal effects of the extracts were assessed. Methanol extracts of A . pinardii , J . dichotoma , and M . dasyantha yielded the highest total flavonoids (TFC) compared to EA and water extracts. The analysis using HPLC-ESI-Q-TOF-MS identified various classes of phytochemicals within the species examined. Aubrieta pinardii extracts were abundant in glucosinolates, whereas J. dichotoma and M. dasyantha extracts were characterized by the presence of coumarins and furanocoumarins. The EA extracts exhibited greater inhibition of microorganism growth compared with MeOH and water extracts. Notably, J. dichotoma showed similar or superior antifungal activity against A. niger (MIC/MFC 0.25/0.50 mg/mL) and M. dasyantha demonstrated comparable efficacy against T. viride (MIC/MFC 0.50/1.00 mg/mL) and P. verrucosum var. cyclopium (MIC/MFC 0.125/0.25 mg/mL) when benchmarked against the reference drug ketoconazole. These results provide valuable information about A . pinardii , J . dichotoma , and M . dasyantha chemical profiles and underline the importance of selecting appropriate solvents for the extraction of metabolites from plant matrix for potential applications in the treatment of various diseases.
Yazarlar (17)
1
Nilofar
2
Gunes Ak
3
Enver Saka
4
Gokhan Zengin
ORCID: 0000-0001-6548-7823
5
Cziaky Zoltan
6
Josef Jeko
7
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
8
Simonetta Cristina Di Simone
ORCID: 0000-0001-5041-3848
9
Mariachiara Gabriele
10
Maria Loreta Libero
ORCID: 0000-0002-8133-5691
11
Giustino Orlando
12
Luigi Menghini
ORCID: 0000-0002-7346-7395
13
Claudio Ferrante
14
Jasmina Glamočlija
15
Mladen Rajaković
16
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
17
Meng Yao Li
ORCID: 0000-0002-7054-448X
Anahtar Kelimeler
Antidiabetic
Antifungal
Aubrieta pinardii
Coumarins
Johrenia dichotoma
Malabaila dasyantha
Kurumlar
Renji Hospital
Shanghai China
Selçuk Üniversitesi
Selçuklu Turkey
University of Belgrade
Belgrade Serbia
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Nyíregyháza
Nyíregyháza Hungary