Scopus
🔓 Açık Erişim
Clinical impact of single nucleotide polymorphisms within interferon signaling pathway gene in pregnant women with COVID-19
Journal of Infection in Developing Countries · Kasım 2025
Makale Bilgileri
DergiJournal of Infection in Developing Countries
Yayın TarihiKasım 2025
Cilt / Sayfa19 · 1584-1591
Scopus ID2-s2.0-105024146174
Erişim🔓 Açık Erişim
Özet
INTRODUCTION: This study aimed to investigate if gene expression modifications due to two different single nucleotide polymorphism (SNP) mutations within the interferon-α/β receptor-2 (IFNAR2) gene had an effect on clinical prognosis in pregnant coronavirus disease 2019 (COVID-19) patients. METHODOLOGY: The study included 173 pregnant patients who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using real-time polymerase chain reaction (RT-PCR). Oligonucleotides were designed for the SNPs with nucleotide database codes rs13050728 and rs2236757 in the hospital's genetic laboratory, and RT-PCR analyses were performed. RESULTS: There was a significant difference in upper respiratory tract infection (URTI) symptoms (runny nose, nasal congestion, and fatigue); between rs2236757 normal-carrier-homozygous mutant pregnant women and the occurrence of symptoms (p = 0.004). However, these URTI symptoms were never seen in homozygous mutant pregnant women. Upon analysis of the relationship between rs13050728 normal-carrier-homozygous mutant pregnant women and the occurrence of symptoms, there was a significant difference between URTI symptoms, and nausea and vomiting (p = 0.001, p = 0.027, respectively). The URTI symptoms were never seen in homozygous mutant and carrier pregnant women. There was no significant association between rs13050728 and rs2236757 normal-carrier-homozygous mutant pregnant women and severity of disease, intensive care unit admission, pregnancy complications, need for oxygen support, and radiologic involvement. CONCLUSIONS: The results of this study will serve as a guide in identifying high-risk individuals, providing treatment, and contributing to the understanding of genetic factors in future viral pandemics.
Yazarlar (8)
1
Burcu Türkseven
ORCID: 0000-0001-5692-4972
2
Nazlım Aktuğ Demir
3
Şua Sümer
4
Onur Ural
5
Ebru Marzioǧlu Özdemir
6
Özlem Seçilmiş Kerimoğlu
ORCID: 0000-0003-2208-8712
7
Tülün Cora
8
Hatice Esranur Kiratlı
Anahtar Kelimeler
COVID-19
IFNAR2
pregnant
SNP
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey