Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Renal Safety and Extrahepatic Defluorination of Sevoflurane in Hepatic Transplantations
Transplantation Proceedings · Haziran 2007
YÖKSİS Kayıtları
Renal Safety and Extrahepatic Defluorination of Sevoflurane in Hepatic Transplantations
Transplantation Proceedings · 2007 SCI
Prof. Dr. BAHAR ÖÇ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Cilostazol and diltiazem attenuate cyclosporine induced nephrotoxicity in rats
2012 ISSN: 0041-1345 SCI-Expanded
Prof. Dr. SERDAR YORMAZ →
The Impact of Pretransplant Hypoalbuminemia on Survival in patients With Leukemia Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT ): a Nutritional Problem
2013 ISSN: 00411345 SCI-Expanded
Prof. Dr. SÜLEYMAN BALDANE →
Biochemical Parameters Renal Function and Outcome of Pregnancy in Kidney Transplant Recipient
2011 ISSN: 00411345 SCI-Expanded
Prof. Dr. GÜLPERİ ÇELİK →
Renal Safety and Extrahepatic Defluorination of Sevoflurane in Hepatic Transplantations
2007 ISSN: 00411345 SCI
Prof. Dr. BAHAR ÖÇ →
Relationship Between Uric Acid, Proteinuria, and Atherogenic Index of Plasma in Renal Transplant Patients
2018 ISSN: 0041-1345 SCI
Prof. Dr. ZEYNEP BIYIK →
Effects of Apocynin on Liver Ischemia-Reperfusion Injury in Rats
2019 ISSN: 0041-1345 SCI-Expanded
Dr. Öğr. Üyesi MERVE GÖKŞİN KARAASLAN TUNÇ →
Makale Bilgileri
ISSN00411345
Yayın TarihiHaziran 2007
Cilt / Sayfa39 · 1544-1548
Scopus ID2-s2.0-34250216632
Özet
Background: The main metabolic pathway for defluorination of sevoflurane in the liver produces inorganic fluoride (Fl). The metabolism and effect of sevoflurane on the kidney is not clear during anhepatic phase in liver transplantation. The goal of the present study was to investigate the metabolism and renal effect of sevoflurane by measuring plasma and urine inorganic fluoride, urinary N-acetyl-glucosaminidase (NAG), and plasma creatinine levels in patients undergoing liver transplantations. Methods: After institutional approval and informed consent, we studied nine cases of orthotopic liver transplantation after anesthesia was induced with 5 mg · kg<sup>-1</sup> thiopental, 1 μg · kg<sup>-1</sup> fentanyl intravenously, the trachea was intubated after vecuronium bromide 0.1 mg · kg<sup>-1</sup>. Anesthesia was maintained with sevoflurane (2%), O<inf>2</inf>, and N<inf>2</inf>O at a total gas flow of 6 L · min<sup>-1</sup> using a semiclosed circle system with a sodalime canister. Blood and urine samples were obtained to measure plasma and urine fluoride concentrations and urinary NAG excretions before induction (P0), hourly during resection (P1, P2, P3), every 15 minutes during anhepatic phase (A1, A2, A3), hourly after reperfusion (neohepatic phase) (N1, N2, N3), and postoperative first hour (Po1). Preoperative (T0) and postoperative day 1 (T1), 3 (T3), 7 (T7) plasma blood urea nitrogen (BUN) and creatinine (Cr) levels were also recorded. Results: Mean duration of surgery was 9:06 ± 0:09 hours. Mean inorganic fluoride concentrations in plasma were in the range of 0.71 ± 0.30 to 28.73 ± 3.31 μmole · L<sup>-1</sup>. In P3, N1, N2, N3, increases in plasma inorganic fluoride concentrations were significant (P < .05) and reached a peak value at Po1. The mean urine inorganic fluoride concentrations were 12.49 ± 2.04 to 256.7 ± 49.62 μmole · L<sup>-1</sup>. In A2, A3, N1, N2, and N3, mean urine inorganic fluoride concentrations were significantly increased (P < .05) and the peak value was observed at Po1. Mean NAG concentrations in urine varied (5.6 ± 1.6 IU · L<sup>-1</sup> to 12.5 ± 1.14 IU · L<sup>-1</sup>) and peak level was observed at 30 minutes of the anhepatic phase (A2), which did not exceed the normal values for urine NAG levels (1.5 to 6.1 U · L<sup>-1</sup>). No impairment was observed in serum BUN and creatinine levels at any time. While there was only a slight increase in NAG during anhepatic phase, there was no change in plasma F1. Conclusions: Sevoflurane seemed to have minimal effect on kidney functions of BUN and Cr levels during liver transplantation. Although urine F1 and NAG levels increased during the anhepatic phase plasma F1, BUN, and Cr levels did not, suggesting that renal F1 production may occur in the absence of hepatic function. The renal effect of sevoflurane in chronic liver disease is controversial and must be investigated in further studies. © 2007 Elsevier Inc. All rights reserved.
Yazarlar (9)
1
Meral Kanbak
2
A. H. Karagöz
3
N. Erdem
4
Bahar Oc
ORCID: 0000-0002-2253-5191
5
Fatma Saricaoglu
6
N. Ertas
7
A. Berkkan
8
O. Abbasoglu
9
Ulku Aypar
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Scimago Dergi (ISSN Eşleşmesi)
Transplantation Proceedings
Q3
SJR Skoru0,298
H-Index93
YayıncıElsevier Inc.
ÜlkeUnited States
Surgery (Q3)
Transplantation (Q3)
Metrikler
8
Atıf
9
Yazar