Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
In vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteries
Bratislava Medical Journal · Ocak 2019
YÖKSİS Kayıtları
In vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteries
Bratisl Med J · 2019 SCI-Expanded
Prof. Dr. JALE BENGİ ÇELİK →
In vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteries
Bratislava Medical Journal · 2019 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
In vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteries
Bratislava Medical Journal-Bratislavske Lekarske Listy · 2019 SCI-Expanded
Prof. Dr. BAHAR ÖÇ →
In vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteries
Bratislava Medical Journal-Bratislavske Lekarske Listy · 2019 SCI-Expanded
Prof. Dr. OĞUZHAN ARUN →
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The effect of acute swimming exercise on plasma leptin in rats
2012 ISSN: 0006-9248 SCI-Expanded
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The effect of acute swimming exercise on plasma melatonin levels in rats
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Prof. Dr. AHMET UZUN →
Selenium supplementation prevents lipid peroxidation caused by arduous exercise in rat brain tissue
2011 ISSN: 0006-9248 SCI-Expanded
Prof. Dr. ESMA MENEVŞE →
Lipid peroxidation in kidney and testis tissues in experimental hypothyroidism the role of zinc
2014 ISSN: 0006-9248 SCI-Expanded
Prof. Dr. MEHMET ERTUĞRUL KAFALI →
Effect of ankaferd blood stopper on hemostasis and histopathological score in experimental liver injury
2010 ISSN: 0006-9248 SCI-Expanded
Prof. Dr. CEYHAN UĞURLUOĞLU →
Histological effects of zinc and melatonin on rat testes
2011 ISSN: 0006-9248 SCI-Expanded 2 atıf
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Effect of boron supplementation on plasma element distribution in ovariectomized rats subjected to acute swimming exercise
2011 ISSN: 0006-9248 SCI-Expanded 2 atıf
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Selenium supplementation prevents lipid peroxidation caused by arduous exercise in rat brain tissue
2011 ISSN: 0006-9248 SCI-Expanded 6 atıf
Prof. Dr. RASİM MOĞULKOÇ →
The effect of acute swimming exercise on plasma melatonin levels in rats
2012 ISSN: 0006-9248 SCI-Expanded 1 atıf
Prof. Dr. RASİM MOĞULKOÇ →
The effect of acute swimming exercise on plasma leptin in rats
2012 ISSN: 0006-9248 SCI-Expanded 1 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Protective effect of melatonin on lipid peroxidation in various tissues of diabetic rats subjected to an acute swimming exercise
2012 ISSN: 0006-9248 SCI-Expanded 2 atıf
Prof. Dr. RASİM MOĞULKOÇ →
The effect of selenium supplementation on elements distribution in liver of rats subject to strenuous swimming
2013 ISSN: 0006-9248 SCI-Expanded
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L thyroxine induced hyperthyroidism affects elements and zinc in rats
2013 ISSN: 0006-9248 SCI-Expanded 1 atıf
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Lipid peroxidation in kidney and testis tissues in experimental hypothyroidism the role of zinc
2014 ISSN: 0006-9248 SCI-Expanded 1 atıf
Prof. Dr. RASİM MOĞULKOÇ →
The comparison of the effects of hepatic regeneration after partial hepatectomy silybum marinaum propofol N acetylcysteine and vitamin E on liver
2012 ISSN: 0006-9248 SCI-Expanded
Prof. Dr. SERDAR YORMAZ →
Protective effect of distillated Nerium oleander on heart of type 2 diabetic rats
2015 ISSN: 0006-9248 SCI-Expanded 1 atıf
Prof. Dr. AHMET LEVENT BAŞ →
Selenium supplementation prevents lipid peroxidation caused by arduous exercise in rat brain tissue
2011 ISSN: 0006-9248 SCI-Expanded 6 atıf
Prof. Dr. ABDULKERİM KASIM BALTACI →
Effect of boron supplementation on plasma element distribution in ovariectomized rats subjected to acute swimming exercise
2011 ISSN: 0006-9248 SCI-Expanded
Prof. Dr. ABDULKERİM KASIM BALTACI →
Histological effects of zinc and melatonin on rat testes
2011 ISSN: 0006-9248 SCI-Expanded 2 atıf
Prof. Dr. ABDULKERİM KASIM BALTACI →
Bacterial translocation and intestinal injury in experimental necrotizing enterocolitis model
2012 ISSN: 0006-9248 SCI-Expanded
Prof. Dr. İLHAN ÇİFTCİ →
Makale Bilgileri
ISSN00069248
Yayın TarihiOcak 2019
Cilt / Sayfa120 · 40-45
Scopus ID2-s2.0-85060648204
Erişim🔓 Açık Erişim
Özet
OBJECTIVE: We aimed to investigate the vasoactive effects of dexmedetomidine on isolated human umbilical arteries and possible mechanisms involved. METHODS: Human umbilical artery strips were suspended in Krebs-Henseleit solution and dose-response curves were obtained for cumulative dexmedetomidine before and after incubation with different agents; propranolol, atropine, yohimbine, prazosin, indomethacin, verapamil. Effects of calcium on cumulative dexmedetomidineinduced contractions were also studied. RESULTS: Cumulative dexmedetomidine resulted in dose dependent contraction responses. Incubation with propranolol (Emax: 93.3 ± 3.26 %), atropine (Emax: 92.0 ± 6.54 %), or indomethacin (Emax: 94.25 ± 2.62 %), did not attenuate dexmedetomidine-elicited contractions (p > 0.05). There were significant decreases in the contraction responses of cumulative dexmedetomidine with yohimbine (Emax: 12.1 ± 11.9 %), prazosin (Emax: 28.8 ± 4.6 %) and verapamil (Emax: 11.2 ± 13.6 %) (p < 0.05). In Ca <sup>+2</sup> free medium contraction responses to cumulative dexmedetomidine was insignificant (Emax: 5.20 ± 3.42 %). Addition of cumulative calcium to the Ca <sup>+2</sup> free medium resulted in concentration dependent increase in contractions (Emax: 64.83 ± 37.7 %) (p < 0.05). CONCLUSION: Dexmedetomidine induces vasoconstriction in endothelial-free umbilical arteries via both, α <inf>1</inf> - and α <inf>2</inf> -adrenergic receptors and also extracellular Ca <sup>+2</sup> concentrations play a major role. β-adrenergic receptors, muscarinic cholinergic receptors, and inhibition of cyclooxygenase enzyme are not involved in this vasoconstriction.
Yazarlar (9)
1
Oguzhan Arun
ORCID: 0000-0001-6101-1481
2
Sengal Taylan
3
I. Duman
4
Bahar Oc
ORCID: 0000-0002-2253-5191
5
Setenay Arzu Yilmaz
6
Ahmet Tekin
7
Çetin Çelik
ORCID: 0000-0001-6165-5092
8
Hulagu Bariskaner
ORCID: 0000-0001-6600-4635
9
Jale Çelik
Anahtar Kelimeler
Alpha adrenergic receptors
Dexmedetomidine
In vitro
Umbilical cord
Vascular smooth muscle
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Bratislava Medical Journal
Q3
SJR Skoru0,458
H-Index42
YayıncıSpringer International Publishing
ÜlkeSlovakia
Medicine (miscellaneous) (Q3)
Metrikler
6
Atıf
9
Yazar
5
Anahtar Kelime