Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Optical Coherence Tomography Biomarkers Predict the Long-Term Restorative Effect of Early Anti-VEGF Treatment on Diabetic Macular Edema
Life · Şubat 2025
YÖKSİS Kayıtları
Optical Coherence Tomography Biomarkers Predict the Long-Term Restorative Effect of Early Anti-VEGF Treatment on Diabetic Macular Edema
Life · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ ŞULE ACAR DUYAN →
Optical Coherence Tomography Biomarkers Predict the Long-Term Restorative Effect of Early Anti-VEGF Treatment on Diabetic Macular Edema
Life · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ AYŞE BOZKURT OFLAZ →
Makale Bilgileri
DergiLife
Yayın TarihiŞubat 2025
Cilt / Sayfa15
Scopus ID2-s2.0-85219007943
Erişim🔓 Açık Erişim
Özet
Background/Purpose: This study compared the effects of three induction doses of anti-vascular endothelial growth factor (anti-VEGF) on diabetic macular edema (DME) with that of long-term treatment using biomarkers to find out the predictability potential of early response to anti-VEGF treatment for the long-term restorative effect. Methods: We retrospectively reviewed the clinical and optical coherence tomography (OCT) data of 71 DME eyes treated with three monthly anti-VEGF doses and followed for 1 year. BCVA, central subfield thickness (CST), subretinal fluid (SRF), intraretinal cysts, hyperreflective foci (HF), disorganization of inner retinal layers (DRILs), ellipsoid zone/external limiting membrane (EZ/ELM) integrity, and vitreoretinal relationships were assessed at baseline, 3, 6, and 12 months. Results: Patients (50.7% male) had a mean follow-up of 12 months. After three anti-VEGF doses, 19 eyes required no additional injections, 25 continued anti-VEGF, 20 switched to dexamethasone implants, and seven received combination therapy. Best corrected visual acuity (BCVA) improved from 0.52 to 0.40 logMAR at 3 months, 0.30 at 6 months, and stabilized at 0.40 at 12 months. CST decreased from 406 µm to 317 µm at 3 months and 307 µm at 12 months. Significant early improvements in BCVA, CST, SRF, and intraretinal cysts were sustained in the long-term follow-up. HF reduction became significant after 6 months, while DRIL and EZ/ELM integrity remained unchanged. Conclusions: The improvement of OCT biomarkers in DME patients supported that intravitreal anti-VEGF significantly restored the retinal microstructure, which was already evident at 3 months in the control after anti-VEGF induction.
Yazarlar (5)
1
Süleyman Okudan
2
Şule Nur Acar Duyan
ORCID: 0000-0002-9319-0477
3
Abdullah Erdem
ORCID: 0009-0003-6253-7049
4
Ayşe Bozkurt Oflaz
ORCID: 0000-0001-5894-0220
5
Banu Turgut Ozturk
Anahtar Kelimeler
anti-VEGF therapy
diabetic macular edema
diabetic retinopathy
optical coherence tomography biomarkers
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
2
Atıf
5
Yazar
4
Anahtar Kelime