Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Management of thyrotoxicosis in children and adolescents: A Turkish multi-center experience
Jcrpe Journal of Clinical Research in Pediatric Endocrinology · Haziran 2019
YÖKSİS Kayıtları
Management of Thyrotoxicosis in Children and Adolescents: A Turkish Multi-center Experience
Journal of Clinical Research in Pediatric Endocrinology · 2019 SCI-Expanded
DOÇENT MUAMMER BÜYÜKİNAN →
Management of Thyrotoxicosis in Children and Adolescents: A Turkish Multi-center Experience
Journal of Clinical Research in Pediatric Endocrinology · 2019 SCI-Expanded
DOÇENT MUAMMER BÜYÜKİNAN →
Management of Thyrotoxicosis in Children and Adolescents: A Turkish Multi-center Experience
Journal of Clinical Research in Pediatric Endocrinology · 2019 SCI-Expanded
DOÇENT MUAMMER BÜYÜKİNAN →
Makale Bilgileri
DergiJcrpe Journal of Clinical Research in Pediatric Endocrinology
Yayın TarihiHaziran 2019
Cilt / Sayfa11 · 164-172
Scopus ID2-s2.0-85067291779
Erişim🔓 Açık Erişim
Özet
Objective: To determine the demographic and biochemical features of childhood and juvenile thyrotoxicosis and treatment outcome. Methods: We reviewed the records of children from 22 centers in Turkey who were diagnosed with thyrotoxicosis between 2007 to 2017. Results: A total of 503 children had been diagnosed with thyrotoxicosis at the centers during the study period. Of these, 375 (74.6%) had been diagnosed with Graves’ disease (GD), 75 (14.9%) with hashitoxicosis and 53 (10.5%) with other less common causes of thyrotoxicosis. The most common presenting features in children with GD or hashitoxicosis were tachycardia and/or palpitations, weight loss and excessive sweating. The cumulative remission rate was 17.6% in 370 patients with GD who had received anti-thyroid drugs (ATDs) for initial treatment. The median (range) treatment period was 22.8 (0.3-127) months. No variables predictive of achieving remission were identified. Twenty-seven received second-line treatment because of poor disease control and/or adverse events associated with ATDs. Total thyroidectomy was performed in 17 patients with no recurrence of thyrotoxicosis and all became hypothyroid. Ten patients received radioiodine and six became hypothyroid, one remained hyperthyroid and restarted ATDs and one patient achieved remission. Two patients were lost to follow up. Conclusion: This study has demonstrated that using ATDs is the generally accepted first-line approach and there seems to be low remission rate with ATDs in pediatric GD patients in Turkey.
Yazarlar (25)
1
İhsan Esen
ORCID: 0000-0003-1700-6778
2
Elvan Bayramoğlu
ORCID: 0000-0002-6732-8823
3
Melek Yildiz
ORCID: 0000-0001-6157-5551
4
Murat Aydin
ORCID: 0000-0001-7374-229X
5
Esin Karakiliç Özturhan
ORCID: 0000-0002-8842-1752
6
Zehra Aycan
ORCID: 0000-0003-4584-2976
7
Semih Bolu
ORCID: 0000-0002-8183-2188
8
Hasan Önal
ORCID: 0000-0001-9676-7086
9
Yilmaz Kör
ORCID: 0000-0003-1645-5416
10
Deniz Ökdemir
ORCID: 0000-0003-3618-8167
11
Edip Ünal
ORCID: 0000-0002-9809-0977
12
Aşan Önder
ORCID: 0000-0002-5730-3198
13
Olcay Evliyaoğlu
ORCID: 0000-0003-4851-8637
14
Atilla Çayir
15
Mehmet Taştan
ORCID: 0000-0003-3712-9433
16
Ayşegül Yüksel
ORCID: 0000-0001-7783-4140
17
Aylin Kilinç
ORCID: 0000-0003-1265-4952
18
Muammer Buyukinan
19
Bahar Özcabi
ORCID: 0000-0002-1089-9326
20
Onur Akın
21
Çiğdem Binay
ORCID: 0000-0002-7749-8818
22
Suna Kilinç
ORCID: 0000-0002-0760-2640
23
Ruken Yildirim
24
Emel Hatun Aytaç
ORCID: 0000-0002-8385-4049
25
Elif Sağsak
ORCID: 0000-0001-7121-1575
Anahtar Kelimeler
Antithyroid drug
Graves’ disease
Hashitoxicosis
Radioactive iodine
Thyrotoxicosis
Total thyroidectomy
Kurumlar
Adana City Hospital
Adana Turkey
Bağcilar Eğitim ve Araştirma Hastanesi
Istanbul Turkey
Corlu State Hospital
Tekirdag Turkey
Çukurova Üniversitesi Tip Fakültesi
Adana Turkey
Derince Training and Research Hospital
Kocaeli Türkiye
Dicle University, Faculty of Medicine
Diyarbakir Turkey
Diyarbakir Pediatric Diseases Hospital
Diyarbakir Turkey
Dr. Sami Ulus Maternity and Children Research and Training Hospital
Ankara Turkey
Düzce Üniversitesi
Duzce Turkey
Erzurum Training and Research Hospital
Erzurum Turkey
Firat Üniversitesi Tip Fakültesi
Elazig Turkey
Gaziantep Üniversitesi
Gaziantep Turkey
Gazi University, Faculty of Medicine
Ankara Turkey
Gülhane Eğitim ve Araştırma Hastanesi
Ankara Turkey
İstanbul Tıp Fakültesi
Istanbul Turkey
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine
Istanbul Turkey
Kanuni Sultan Suleyman Training and Research Hospital
Istanbul Turkey
Konya Meram Training and Research Hospital
Konya Turkey
Ondokuz Mayis University, Medical School
Samsun Turkey
T.C. Saglik Bakanligi Istanbul Goztepe Egitim ve Arastirma Hastanesi
Goztepe Turkey
T. C. Sağlık Bakanlığı, Taksim Eğitim ve Araştirma Hastanesi
Istanbul Turkey
Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital
Istanbul Turkey
Metrikler
6
Atıf
25
Yazar
6
Anahtar Kelime