Scopus
YÖKSİS Eşleşti
Effects of genetic polymorphisms of CYP2J2, CYP2C9, CYP2C19, CYP4F2, CYP4F3 and CYP4A11 enzymes in preeclampsia and gestational hypertension
Placenta · Haziran 2023
YÖKSİS Kayıtları
Effects of genetic polymorphisms of CYP2J2, CYP2C9, CYP2C19, CYP4F2, CYP4F3 and CYP4A11 enzymes in preeclampsia and gestational hypertension
Placenta · 2023 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MERT CAN ONGUN →
Makale Bilgileri
DergiPlacenta
Yayın TarihiHaziran 2023
Cilt / Sayfa137 · 88-95
Scopus ID2-s2.0-85153946051
Özet
Introduction: The aim of this study was to investigate the effects of cytochrome P450 (CYP) 2J2, CYP2C9, CYP2C19 and CYP4F2, CYP4F3 and CYP4A11 genetic polymorphisms in preeclampsia and gestational hypertension (GHT) patients in a sample of Turkish population. Materials-methods: Patients (n = 168; 110 GHT and 58 preeclampsia) and healthy pregnant women (n = 155, controls) participated in the study. For genotyping, polymerase chain reaction (PCR) and restriction analysis (RFLP) were used. Substance levels were measured using LC-MS. Results: Plasma DHET levels in GHT and preeclampsia patients were significantly lower than those in the control group (62.7%, 66.3% vs.100.0%, respectively, p < 0.0001). An increase in CYP2J2*7 allele frequency was observed in the preeclampsia group, as compared to GHT group (12.1% vs. 4.5%; odds ratio, O.R. = 2.88, p < 0.01). The frequencies of CYP2C19*2 and*17 alleles were higher in GHT group as compared to the control group (17.7% vs. 11.6%, O.R. = 1.99, p < 0.01; and 28.6% vs.18.4%, O.R. = 2.03, p < 0.01, respectively). An increased frequency of CYP4F3 rs3794987 G allele was found in GHT group as compared to the control group (48.0% vs. 38.0%; O.R. = 1.53, p < 0.01). Discussion: DHET plasma levels were significantly reduced in hypertensive pregnant groups as compared to the control group. The allele frequency distributions for CYP2J2*7, CYP2C19 *2, *17 and CYP4F3 rs3794987 were significantly different in hypertensive pregnant patients as compared to the healthy control subjects. Our results may suggest that investigated genetic polymorphisms may be useful in diagnosis and clinical management of GHT and preeclampsia patients.
Yazarlar (9)
1
Mert C. Ongun
ORCID: 0000-0002-5222-5936
2
Nazan Vanlı Tonyalı
ORCID: 0000-0002-7284-6887
3
Ozan Kaplan
4
Ilter Deger
5
Mustafa Celebier
6
Nursabah E. Basci Akduman
7
Dilek Şahin
ORCID: 0000-0001-8567-9048
8
Aykan Yücel
9
Melih O. Babaoglu
Anahtar Kelimeler
Cytochrome P450 (CYP)
Gestational Hypertension
Pharmacogenomics
Preeclampsia
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
University of Health Sciences
Istanbul Turkey
Metrikler
2
Atıf
9
Yazar
4
Anahtar Kelime