Scopus
YÖKSİS Eşleşti
Contractile effect of trimethylamine and trimethylamine-n-oxide on isolated human umbilical arteries
Journal of Obstetrics and Gynaecology Research · Temmuz 2023
YÖKSİS Kayıtları
Contractile effect of trimethylamine and trimethylamine‐n‐oxide on isolated human umbilical arteries
Journal of Obstetrics and Gynaecology Research · 2023 SCI-Expanded
PROFESÖR ÇETİN ÇELİK →
Contractile effect of trimethylamine and trimethylamine‐n‐oxide on isolated human umbilical arteries
The Journal of Obstetrics and Gynaecology Research · 2023 SCI-Expanded
PROFESÖR ÇETİN ÇELİK →
Contractile effect of trimethylamine and trimethylamine‐n‐oxide on isolated human umbilical arteries
Journal of Obstetrics and Gynaecology Research · 2023 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MERT CAN ONGUN →
Contractile effect of trimethylamine and trimethylamine‐n‐oxide on isolated human umbilical arteries
Wiley · 2023 SCI-Expanded
PROFESÖR HÜLAGU BARIŞKANER →
Contractile effect of trimethylamine and trimethylamine‐n‐oxide on isolated human umbilical arteries
The Journal of Obstetrics and Gynaecology Research · 2023 SCI-Expanded
PROFESÖR GÖKÇEN ÖRGÜL →
Makale Bilgileri
DergiJournal of Obstetrics and Gynaecology Research
Yayın TarihiTemmuz 2023
Cilt / Sayfa49 · 1736-1742
Scopus ID2-s2.0-85152793744
Özet
Background: The aim of this study is to investigate the effect of trimethylamine (TMA) and trimethylamine-n-oxide (TMAO) on the contractility of human umbilical artery and the possible mechanisms involved. Methods: Vasoactive responses to TMA and TMAO on human umbilical artery rings were measured in isolated organ baths. Cumulative dose–response curves for TMA and TMAO were obtained before and after incubation with atropine, yohimbine, prazosin, indomethacin, verapamil, and Ca<sup>+2</sup>-free Krebs–Henselite solution. Results: Administration of cumulative TMA and TMAO resulted in dose-dependent contraction at concentrations ranging from 10 to 100 mM on human umbilical artery rings. TMA-induced contractions were more potent than TMAO-induced contractions (TMA: −logEC50 = 1.00 ± 0.02, TMAO: −logEC50 = 0.57 ± 0.02). Contraction responses to TMA were significantly lower in the presence of verapamil and in the absence of external Ca<sup>+2</sup> (p < 0.001, p < 0.05, respectively). Conclusion: Our results showed that TMA and TMAO caused vasoconstriction in isolated human umbilical artery rings. Our findings also indicated that TMA but not TMAO-induced vasoconstriction was partially dependent on extracellular Ca<sup>2+</sup> and calcium influx through L-type Ca<sup>2+</sup> channels. Our results suggest that TMA and TMAO may have the potential to contribute to cardiovascular diseases through their direct effect on vascular contractility in human arteries.
Yazarlar (4)
1
Mert C. Ongun
ORCID: 0000-0002-5222-5936
2
Gökçen Örgül
ORCID: 0000-0003-0578-4230
3
Çetin Çelik
ORCID: 0000-0001-6165-5092
4
Hulagu Bariskaner
ORCID: 0000-0001-6600-4635
Anahtar Kelimeler
human umbilical artery
isolated organ bath
trimethylamine
trimethylamine-n-oxide
vascular diseases
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
2
Atıf
4
Yazar
5
Anahtar Kelime