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Esculetin induce apoptosis in Human Cervical Cancer Cells

Eastern Journal of Medicine · Ocak 2024

YÖKSİS DOI Eşleşmesi Bulundu

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YÖKSİS Kayıtları
Esculetin induce apoptosis in Human Cervical Cancer Cells (HeLa)
Eastern Journal Of Medicine · 2024 Scopus
Prof. Dr. ÇETİN ÇELİK →
Esculetin induce apoptosis in Human Cervical Cancer Cells
Eastern Journal of Medicine · 2024 TR DİZİN
Prof. Dr. ÇETİN ÇELİK →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 11 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
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2023 ISSN: 1301 - 0883 TR DİZİN
Doç. Dr. ALİ FURKAN BATUR →
Results of Continence Protective Levator Ani Urethral Suspension and Rhabdosphincter Remodeling Anastomosis Method in Radical Retropubic Prostatectomy
2023 ISSN: 1301-0883 TR DİZİN
Prof. Dr. MEHMET KAYNAR →
Results of Continence Protective Levator Ani Urethral Suspension and Rhabdosphincter Remodeling Anastomosis Method in Radical Retropubic Prostatectomy
2023 ISSN: 1301-0883 TR DİZİN
Doç. Dr. ALİ FURKAN BATUR →
Prenatal diagnosis of congenital pulmonary airway malformation (CPAM) types: Case series
2024 ISSN: 1301-0883 TR DİZİN
Prof. Dr. GÖKÇEN ÖRGÜL →
Measuring Out-of-Field Dose to The Whole Brain in Radiotherapy
2024 ISSN: 1301-0883 TR DİZİN
Doç. Dr. OSMAN VEFA GÜL →
Esculetin induce apoptosis in Human Cervical Cancer Cells (HeLa)
2024 ISSN: 1301-0883 Scopus
Prof. Dr. ÇETİN ÇELİK →

Makale Bilgileri

Dergi Eastern Journal of Medicine
ISSN13010883
Yayın TarihiOcak 2024
Cilt / Sayfa29 · 18-21
DOI10.5505/ejm.2024.25564
Scopus ID2-s2.0-85198846413
Erişim🔓 Açık Erişim
Özet Despite the development of effective HPV screening and vaccination programs in women, cervical c ancer ranks first in cancer-related deaths. In order to prevent the side effects of chemotherapeutic agents, studies on the use of natural compounds in the treatment of cervical cancer are becoming increasingly common. Esculetin, a coumarin derivative from natural compounds, is a pharmacological substance with anti-inflammatory, antioxidant, anti-tumor, neuroprotective effects. In various studies, esculetin has been found to induce apoptosis in colon cancer, breast cancer, and cervical cancer via JNK, ERK, ROS mediated mitochondrial pathway or ER stress activation pathways. HeLa cells and HEK cells were cultured. MTT analysis was performed to determine the IC50 dose of the esculetin. Expression levels of apoptotic genes (BAX, BAK, BAD, APAF-1 and p53) and antiapoptotic genes (BCL-2, BCL-XL) were detected by qPCR. The IC50 dose at which esculetin inhibited the viability of HeLa cells was determined as 800 μM. In addition, esculetin down-regulated antiapoptotic genes BCL-2 and BCL-XL, while up-regulated apoptotic genes such as BAK, APAF-1, p53, BAD, BAX. Current findings showed that esculetin has apoptotic effects on HeLa cells.

Yazarlar (4)

1
Tugce Duran
ORCID: 0000-0002-7353-4527
2
Gözde Şahin
ORCID: 0000-0003-3067-9125
3
Ayşe Gül Kebapçilar
4
Çetin Çelik
ORCID: 0000-0001-6165-5092

Anahtar Kelimeler

Apoptosis cervical cancer Esculetin HeLa cell

Kurumlar

Basaksehir Cam and Sakura City Hospital
Istanbul Turkey
Karatay Üniversitesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Eastern Journal of Medicine
Q4 OA
SJR Skoru0,146
H-Index14
YayıncıYuzuncu Yil Universitesi Tip Fakultesi
ÜlkeTurkey
Medicine (miscellaneous) (Q4)
Dergi sayfasına git

Metrikler

2
Atıf
4
Yazar
4
Anahtar Kelime

Sistemimizdeki Yazarlar

ÇÇ
ÇETİN ÇELİK
Prof. Dr.

Hızlı Erişim

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